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Metabolomic Profile clinical trials

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NCT ID: NCT04506385 Completed - Metabolomic Profile Clinical Trials

Metabolomic Effects of Probiotics Administration

MAPPINg
Start date: April 20, 2020
Phase: N/A
Study type: Interventional

Background: The establishment of the beneficial interactions between the host and its microbiota is essential for the development and correct functioning of the organism, since microflora alterations can lead to many chronic degenerative diseases. In this context, probiotics are used to improve balanced microbial communities and therefore exert substantial health-promoting effects to the host. Objective: The aim of the present study is to monitor the molecular outcomes, obtained by gut microflora modulation through probiotic treatment, on human urine and serum metabolic profiles, with a 1H-Nuclear Magnetic Resonance -based metabolomic approach.

NCT ID: NCT01686477 Completed - Insulin Resistance Clinical Trials

PREterM FOrmula Or Donor Breast Milk for Premature Babies

PREMFOOD
Start date: April 2, 2013
Phase: N/A
Study type: Interventional

In order to address this crucial question, central to preterm newborn care, a multicentre United Kingdom (UK) -wide study randomising 4000 preterm babies would be necessary to achieve sufficient power to evaluate the impact on the short-term outcomes necrotising enterocolitis and bloodstream infection, and establish cohorts large enough to address long-term metabolic (such as obesity, type 2 diabetes), cardiovascular (such as blood pressure) and developmental outcomes. This pilot trial will evaluate the practicability and feasibility of such a large multicentre UK randomised controlled trial. In addition to evaluating feasibility and to ensure maximal use of resources allocated, this study will also assess outcomes that are indicative of long term metabolic health.