Metabolism in Adipose Tissue Clinical Trial
Official title:
Metabolism in Adipose Tissue Followed Following Sprint Exercise
Verified date | September 2020 |
Source | Karolinska Institutet |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Low volume sprint exercise training has been shown to reduce body fat despite small total energy expenditure (for ref see Gillen and Gibala 2014). IL-6 has been shown to increase adipose tissue lipolysis in vitro. Therefore, in an initial study on effects of sprint exercise on adipose tissue metabolism the investigators will examine acute short-term exercise effects on adipose tissue IL-6 exchange.
Status | Completed |
Enrollment | 18 |
Est. completion date | September 2017 |
Est. primary completion date | September 2016 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 20 Years to 40 Years |
Eligibility |
Inclusion Criteria: - Physical active - Healthy Exclusion Criteria: - Smokers - Pregnant - On medication - No infection - No asthma |
Country | Name | City | State |
---|---|---|---|
Sweden | Karolinska Institutet/Karolinska University Hospital | Stockholm |
Lead Sponsor | Collaborator |
---|---|
Karolinska Institutet |
Sweden,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Il-6 secretion in adipose tissue before and after 30-s repeated sprint exercise | Stomach fat biopsies and arterial and stomach vein blood are obtained | Before 30-s repeated sprint exercise | |
Primary | Il-6 secretion in adipose tissue before and after 30-s repeated sprint exercise | Stomach fat biopsies and arterial and stomach vein blood are obtained | After 30-s repeated sprint exercise | |
Secondary | Changes in blood flow in adipose tissue | Xenon-133 is administered by a subcutaneous injection into the abdominal adipose tissue of approximately 1-2 MBq of Xenon-133 in the form of gas, at rest before work. | Before 30-s repeated sprint exercise | |
Secondary | Changes in blood flow in adipose tissue | The rinsing rate of Xenon-133 from the tissue depot is continuously recorded during the study period by a non-invasive method using a portable scintillation detector system (Mediscint) up to 60 minutes after the last sprint work. | After 30-s repeated sprint exercise | |
Secondary | Changes in different metabolites | Analysed for lactate, ammonia and IL-6 | Before 30-s repeated sprint exercise | |
Secondary | Changes in different metabolites | Analysed for lactate, ammonia and IL-6 | After 30-s repeated sprint exercise |