The Reproducibility and Clinical Utility of an Abbreviated Fat Tolerance Test

Metabolic Syndrome Clinical Trial

Official title:

The Reproducibility and Clinical Utility of an Abbreviated Fat Tolerance Test

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04437459
• Other study ID #: HS1844
• Status: Completed
• Phase: N/A
• Start date: October 8, 2018
• Est. completion date: July 31, 2019

Study information

• Verified date: June 2020
• Source: Oklahoma State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study aims to evaluate the reliability of a shortened fat tolerance test ("abbreviated fat tolerance test", or "AFTT") for measuring post-meal lipids in human blood. The reliability of the triglyceride results in this test are compared to the reliability of the glucose results from an oral glucose tolerance test (OGTT), a widely-used and clinically accepted metabolic test.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: July 31, 2019
• Est. primary completion date: July 31, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Free of chronic disease

• Normal (healthy) fasting glucose and triglycerides

Exclusion Criteria:

• Presence of pace-maker

• Pregnant

• Using tobacco products

• Using medications or dietary supplements that could modify primary outcomes

Related Conditions & MeSH terms

• Dyslipidemias
• Metabolic Syndrome

Intervention

Other:
• High-fat shake
Participant consumes a high-fat test shake. Blood is drawn before and 4 hours after this shake to measure triglycerides.
• Pure glucose solution
Participant consumes 75 grams of pure glucose. Blood is drawn before and 2 hours after this drink to measure glucose.

Locations

Country	Name	City	State
United States	Oklahoma State University	Stillwater	Oklahoma

Sponsors (1)

Lead Sponsor	Collaborator
Oklahoma State University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reliability of the Change in Triglycerides after a High-Fat Meal	Participants complete two fat tolerance tests. In each test, triglycerides are measured in blood immediately before and 4 hours after consumption of a high-fat meal. The reliability/agreement in measuring the triglyceride change between the 2 tests is being determined.	The two fat tolerance tests are separated by 1 week.
Primary	Reliability of the Change in Glucose after Ingestion of a Glucose Solution	Participants complete two glucose tolerance tests. In each test, glucose is measured in blood immediately before and 2 hours after consumption of a pure glucose solution. The reliability/agreement in measuring the glucose change between the 2 tests is being determined.	The two glucose tolerance tests are separated by 1 week.