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Statins in Chronic Hepatitis C Patients Receiving Sofosbuvir/Daclatasvir Combination

Metabolic Syndrome Clinical Trial

Official title:
Benefits of Statins in Chronic Hepatitis C Patients Receiving Sofosbuvir/Daclatasvir Combination

Clinical Trial Summary

The purpose of the study is to determine if statin can affect the clinical outcome of chronic hepatitis C patients receiving Sofosbuvir/Daclatasvir/Ribavirin combination

Clinical Trial Description

Aim of the work

To determine the benefits of statin use in CHC patients treated with Sofosbuvir/Daclatasvir/Ribavirin through :

Primary Outcome: Assessment of therapeutic SVR12

Seconadry Outcome

1. assessment of Chronic hepatitis C(CHC) infection risk on development of metabolic syndrome through assessment of lipid profile , fasting glucose test , HgbA1C and C-reactive protein(CRP).

2- Evaluation of CHC related complications such as fibrosis and cirrhosis

Patients will be followed up for the whole study period and will be subjected to assessment of the following:

1. CBC , liver function test , lipid profile and CK every month till the end of therapy.

2. HgA1C and CRP at the end of therapy.

3. HCV-PCR test 3 months after the end of therapy.

4. Fibrosis using (FIB-4) 3 months after the end of therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03490097
Study type Interventional
Source Ain Shams University
Contact
Status Completed
Phase Phase 2/Phase 3
Start date December 1, 2017
Completion date May 23, 2018
View Details
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