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Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism

Metabolic Syndrome Clinical Trial

Official title:
Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism

Clinical Trial Summary

Aim 1.Test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system impairs glycemic control via effects on insulin sensitivity and insulin secretion. Aim 2. Test the hypothesis that activation of the endogenous renin-angiotensin-aldosterone system impairs insulin secretion and insulin sensitivity via an mineralocorticoid-receptor dependent mechanism.

Clinical Trial Description

In aim 1 subjects are randomized to cross over between an 8 day high salt and 8 day low salt diet and assessments are made. In aim 2, subjects are randomized to a 2x2 cross over study with an 8 day low salt diet and either eplerenone 50mg or amlodipine 5mg. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02034435
Study type Interventional
Source Vanderbilt University Medical Center
Contact
Status Completed
Phase Phase 4
Start date October 2013
Completion date December 2019
View Details
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