Metabolic Syndrome Clinical Trial
There is some evidence to suggest that obesity is a risk factor for the development of
cognitive dysfunction, although this is not a universal finding. This discordance might be
ascribed to the existence of a 'healthy obese phenotype'- that is, obesity in the absence of
metabolic risk factors. We examined whether the association of obesity with cognitive
dysfunction is dependent on the individual's metabolic health.
60 obese patients' undergoping liver fibroscan and blood tests will be enrolled. Obesity was
defined as body mass index ≥ 30 kg/m2. Based on blood pressure, HDL-cholesterol,
triglycerides, glycated haemoglobin, and C-reactive protein, participants were classified as
'metabolically healthy' (0 or 1 metabolic abnormality) or 'unhealthy' (≥ 2 metabolic
abnormalities). Cognitive dysfunction will be assessed by moca and minimental score.
Results: Cognitive dysfunction prevalence is expected in 30% , but 50% of this group was
categorized as metabolically healthy. Relative to non-obese healthy participants, after
adjustment for baseline covariates, the metabolically unhealthy obese participants had
elevated risk of cognitive dysfunction although the metabolically healthy obese did not. The
association between obesity and risk of cognitive dysfunction appears to be partly dependent
on metabolic health, although further work is required to confirm these findings.
In obesity there is an increase in oxidative stress due to metabolic syndrome . Thus obese
patients suffer from higher incidences of cardiovascular complications such as
atherosclerosis as compare to non- obese population. Haptoglobin (Hp) is a plasma protein
which binds free hemoglobin and prevents it from heme- iron mediated oxidation. There are
three different types of Hp which differ in their antioxidant ability. Several clinical
studies have shown that Hp 2-2 genotype is associated with higher incidence of
cardiovascular diseases.
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