The BANGALORE Study; Combination of Berberine, Lipoic Acid, and Picrorhiza

Metabolic Syndrome Clinical Trial

— CAR-191  

Official title:

Changes in Appetite, Weight, Body Composition, Endothelial Function and Biomarkers in Patients With the Cardiometabolic Syndrome: Comparison of a Combination of Berberine, Lipoic Acid, and Picrorhiza (CAR-191) Versus Placebo (The "BANGALORE" Study)

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01696448
• Other study ID #: AVR-2012-01
• Status: Completed
• Phase: N/A
• First received: August 13, 2012
• Last updated: November 10, 2014
• Start date: August 2012
• Est. completion date: April 2013

Study information

• Verified date: November 2014
• Source: Carmel Biosciences
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Though medical treatment has been effective in the treatment of cardiometabolic diseases (including coronary atherosclerosis and diabetes mellitus), the incidence of these disorders continues to be high. Many reasons are responsible, but lifestyle changes, including an increased prevalence of obesity and the metabolic syndrome, are significant for this cause. Diagnosis and treatment of obese patients with hypertension requires that health care providers address the issues of hypertension, glucose intolerance, body weight and dyslipidemia. A sedentary lifestyle and poor cardiorespiratory fitness are not only associated with the (cardio) metabolic syndrome but could actually be considered features of the metabolic syndrome. These issues are significant in the health of certain individuals, who experience greater difficulty in treated BP control, experience increased hypertensive and diabetic complications, and have higher levels of obesity.

In this study, the investigators will evaluate the efficacy of the nutritional supplements berberine, alpha-lipoic acid, and picrorhiza (CAR-191) when consumed 30 minutes before meals, on appetite suppression, body composition and weight control. Additionally, the investigators will evaluate the effects of this combination of nutraceuticals on the mechanistic effects of oxidation, inflammation, and vascular function in a high-risk population with the metabolic syndrome.

Primary Objective To assess the comparative effect of a combination (known as CAR-191) of berberine (200 mg), alpha-lipoic acid (150 mg), and picrorhiza (100 mg) three times a day, compared to placebo three times a day, on parameters relate to appetite suppression, weight control and body composition in a high risk population with the metabolic syndrome.

Secondary Co-objectives

To evaluate the effects of CAR-191 versus placebo on changes in:

• Endothelial function using noninvasive brachial artery reactivity (BAR) ultrasound

• Biomarkers including IL-6, HOMA-IR, HbA1C, hsCRP, adiponectin, plasma/urine isoprostanes, PAI-1, TNFα-II, aldosterone, and glutathione redox ratio

• Urinary protein excretion

• Clinical chemistry including plasma glucose, blood urea nitrogen, creatinine, total bilirubin, uric acid, transaminases (SGOT/AST, SGPT/ALT), alkaline phosphatase, C-reactive protein, and lipoproteins

Description:

Though medical treatment has been effective in the treatment of cardiometabolic diseases (including coronary atherosclerosis and diabetes mellitus), the incidence of these disorders continues to be high. Many reasons are responsible, but lifestyle changes, including an increased prevalence of obesity and the metabolic syndrome, are significant for this cause. Recent reported guidelines by the JNC-VII and National Cholesterol Education Panel/ATP-III suggest that blood pressure reduction is effective in improving the overall quality of life and may be helpful in the prevention of cardiovascular disease.

Diagnosis and treatment of obese patients with hypertension requires that health care providers address the issues of hypertension, glucose intolerance, body weight and dyslipidemia. Strategies to promote therapeutic lifestyle change (TLC), specifically increased physical activity and reduced dietary intake resulting in weight loss, are not as well defined. A sedentary lifestyle and poor cardiorespiratory fitness are not only associated with the (cardio) metabolic syndrome but could actually be considered features of the metabolic syndrome. These issues are significant in the health of certain individuals, who experience greater difficulty in treated BP control, experience increased hypertensive and diabetic complications, and have higher levels of obesity.

In this study, the investigators will evaluate the efficacy of the nutritional supplements berberine, alpha-lipoic acid, and picrorhiza (CAR-191) when consumed 30 minutes before meals, on appetite suppression, body composition and weight control. Additionally, the investigators will evaluate the effects of this combination of nutraceuticals on the mechanistic effects of oxidation, inflammation, and vascular function in a high-risk population with the metabolic syndrome.

The investigators will evaluate the initiation of CAR-191 in patients which meet at least 3 of the 5 criteria (ATP-III guidelines) for the cardiometabolic syndrome. The investigators will determine whether the CAR-191 combination as compared to placebo provides benefit in appetite suppression, body composition and certain clinical endpoints, including effects on endothelial function, lipid levels, and glucose control. This study will analyze the effects of 12 week administration of CAR-191 versus placebo on these parameters in a population of patients (n=40) with the cardiometabolic syndrome. The study has a parallel design consisting of 2 weeks of washout and then 12 weeks of treatment to either CAR-191 or placebo. The total study period is 14 weeks. Patients will be assigned to the CAR-191 or placebo group in a 3:1 ratio so that 30 patients will receive CAR-191 and 10 patients will receive placebo. See attached study design.

Primary Objective To assess the comparative effect of a combination (known as CAR-191) of berberine (200 mg), alpha-lipoic acid (150 mg), and picrorhiza (100 mg) three times a day, compared to placebo three times a day, on parameters relate to appetite suppression, weight control and body composition in a high risk population with the metabolic syndrome.

Secondary Co-objectives

To evaluate the effects of CAR-191 versus placebo on changes in:

• Endothelial function using noninvasive brachial artery reactivity (BAR) ultrasound

• Biomarkers including IL-6, HOMA-IR, HbA1C, hsCRP, adiponectin, plasma/urine isoprostanes, PAI-1, TNFα-II, aldosterone, and glutathione redox ratio

• Urinary protein excretion

• Clinical chemistry including plasma glucose, blood urea nitrogen, creatinine, total bilirubin, uric acid, transaminases (SGOT/AST, SGPT/ALT), alkaline phosphatase, C-reactive protein, and lipoproteins

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: April 2013
• Est. primary completion date: April 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

• Male and female subjects = 18 years and = 80 years with (cardio)metabolic syndrome as identified by investigators, OR

• Male and female subjects = 18 years and = 80 years with (cardio)metabolic syndrome defined by ATP-III criteria:

Insulin resistance, identified by 1 of the following

• Type 2 diabetes with HgA1C < 8.0% or on medical therapy

• Impaired fasting glucose

• Impaired glucose tolerance

• Or for those with normal fasting glucose levels (<100 mg/dl), glucose uptake below the lowest quartile for background population under investigation under hyperinsulinemic, euglycemic conditions

Plus any 2 of the following:

• Plasma triglycerides = 150 mg/dl (= 1.7 mmol/L)

• HDL cholesterol <35 mg/dl (<0.9 mmol/L) in men or <39 mg/dl) (1.0 mmol/L) in women

• BMI >30 kg/m2 and/or waist:hip ratio > 0.9 in men, >0.85 in women

• Urinary albumin excretion rate = 20 µg/min or albumin:creatinine ratio = 30 mg/g

Exclusion Criteria:

• • Females of childbearing potential who are pregnant, lactating or who do not employ adequate birth control procedures.

• Presence of any serious disorder including, renal, pulmonary, hepatic, gastrointestinal, endocrine/metabolic (with the exception of non-insulin dependent type 2 diabetes), hematologic/oncologic, neurologic and psychiatric diseases are exclusionary.

• History of heart failure.

• Stroke or heart attack within past 6 months.

• Use of insulin.

• Non-dominant upper arm circumference greater than 50 cm. (19.5 inches)

• Currently using any prescription or over-the-counter weight loss products

• Previous bariatric surgery or other weight reduction procedures

• Weight loss or gain of greater than 15 pounds in the last 3 months

• Past or current diagnosis of an eating disorder

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Metabolic Syndrome
• Metabolic Syndrome X

Intervention

Dietary Supplement:
• CAR-191
Patients will be randomized to the CAR-191 intervention group in a 3:1, CAR0-191:placebo ratio. There will be 30 patients in the CAR-191 treatment group.

Other:
• Placebo
Patients will be randomised in a 3:1 ratio. There will be 10 patients in the placebo group.

Locations

Country	Name	City	State
United States	Atlanta Vascular Research Foundation	Atlanta	Georgia

Sponsors (2)

Lead Sponsor	Collaborator
Carmel Biosciences	Atlanta Vascular Research Foundation

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	appetite suppression	Change in appetite will be measured through food frequency and appetite questionnaires	12 weeks	No
Secondary	Endothelial function using noninvasive brachial artery reactivity (BAR) ultrasound		12 weeks	No
Secondary	Weight control	Weight will be measured as body weight in lbs and BMI to see if treatment results in weight loss	12 weeks	No
Secondary	Body Composition	Body composition will be measured as body fat percentage, fat mass, fat-free mass and waist to hip ratio.	12 weeks	No