Effects of an Amino-acid Supplement on Hepatic Lipid Metabolism

Metabolic Syndrome Clinical Trial

— AMINOFRUCT  

Official title:

Effects of a Supplementation With Amino-acids on Hepatic Lipid Metabolism

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01119989
• Other study ID #: protocole 51/10
• Status: Completed
• Phase: N/A
• Start date: May 2010
• Est. completion date: December 2011

Study information

• Verified date: May 2018
• Source: University of Lausanne
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

10 healthy male volunteers will be studied after

• a 6 day weight maintenance, balanced diet

• a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day

• a 6 days weight maintenance, balanced diet supplemented with 3 grams fructose/kg body weight/day and 20g amino-acids per day At the end of each 6 days period, the following measurements will be obtained

• intrahepatic lipids (1H-MRS)

• metabolic effects of fructose ingestion (measurement of substrate oxidation, gluconeogenesis from fructose, palmitate synthesis from fructose, plasma VLDL-kinetics)

This is a randomized, double blinded study

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: December 2011
• Est. primary completion date: March 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• age 18-30 years

• sex: males

• BMI between 19 and 25 kg/m2

• less than 3 30min- exercise session/week

Exclusion Criteria:

• smokers

• alcohol consumption more than 50g/week

• consumption of drugs

• history of diabetes in first degree relatives

• presence of ferro-magnetic prosthesis, cardiac pacemakers, or any contra-indication to NMR

Related Conditions & MeSH terms

• Metabolic Syndrome
• Metabolic Syndrome X

Intervention

Dietary Supplement:
• Fructose+maltodextrin placebo

• amino-acid + fructose

Locations

Country	Name	City	State
Switzerland	Centre Hospitalier Universitaire Vaudois	Lausanne	VD

Sponsors (2)

Lead Sponsor	Collaborator
University of Lausanne	University of Bern

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	intrahepatic lipids		after 6 days on each controlled diet
Secondary	13C palmitate synthesis		after 6 days on each controlled diet