Clinical Trials Logo
  1. Home
  2. Metabolic Disturbance
  3. NCT03697928

Markers of Carnitine Acetyltransferase (CrAT) Protein Activity and Carnitine Availability

Metabolic Disturbance Clinical Trial

Official title:
Searching for Non-invasive Magnetic Resonance-based Markers for CrAT Protein Activity and Carnitine Availability in Skeletal Muscle

Clinical Trial Summary

This study aims to measure skeletal muscle metabolism in vivo during exercise using the non-invasive Magnetic Resonance Spectroscopy (MRS) technique. Specifically, phosphocreatine (PCr) kinetic and Acetylcarnitine levels will be determined at resting, during exercise and during the recovery post exercise. The target population is adult healthy men, with a wide range of maximal physical capacity.

Clinical Trial Description

Skeletal muscle mitochondrial activation during the transition from resting metabolism to exercise may modulated by CrAT activity. Furthermore, dynamic changes in acetylcarnitine during the transition from exercise to resting metabolism (acetylcarnitine off-kinetic) may also reflect the action of CrAT protein. To date, the only possibility to get information on CrAT activity is by taking a muscle biopsy and perform enzyme activity assays ex vivo. By dynamic MRS scanning, it might be possible to deduce information that reflects CrAT activity, thereby making the biopsy sampling unnecessary. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03697928
Study type Observational
Source Maastricht University
Contact
Status Completed
Phase
Start date March 12, 2019
Completion date February 1, 2020
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT04528004 - Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure Early Phase 1
Completed NCT04597983 - Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists N/A
Completed NCT03445234 - Blueberries, Bananas, Exercise Recovery N/A
Recruiting NCT04892199 - Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication? Phase 4
Active, not recruiting NCT05070585 - Isothiocyanates and Metabolic Health Phase 1/Phase 2
Not yet recruiting NCT05494151 - Metabolic Substrate of Patients With Myocardial Infarction With and Without Modifiable Cardiovascular Risk Factors
Completed NCT04787952 - Insight Into New Brown Adipose Tissue Activators.
Completed NCT05758857 - Multiple Risk Factor Intervention Trial N/A
Completed NCT02689882 - "Pharmacokinetic Study of Nicotinamide Riboside" Phase 1
Completed NCT01674426 - Pathogenesis of Functional Hypothalamic Amenorrhea N/A
Recruiting NCT06252922 - Diet-Induced Changes in GEnetic Material
Completed NCT06326840 - Clinical Efficacy and Adverse Reactions of Antipsychotic Treatment N/A
Recruiting NCT06345937 - Multiple Risk Factor Intervention Trial (Ms. FIT) N/A
Recruiting NCT06392360 - Betaine, Exercise Performance, and Gut Permeability N/A
Completed NCT04009642 - Cardiac Rest and Stress Metabolism in Patients With Type 2 Diabetes
Withdrawn NCT03515642 - Exercise, Gut Microbiota in Sedentary Adults With Overweight N/A
Recruiting NCT06333184 - Smoothies and Blood Sugars N/A
Not yet recruiting NCT05773183 - Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men
Completed NCT04266665 - Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome Phase 4
Recruiting NCT04469790 - Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children N/A