Metabolic Clearance Rate Clinical Trial
Official title:
Induction of Drug Metabolism: A Comparative, Pharmacokinetic in Vivo Study of the Effect of Carbamazepine and Oxcarbazepine on CYP3A4.
This is a study of the possible effect of two antiepileptic drug on enzymes in the liver
that metabolizes a number of drugs. It is a well know fact that carbamazepine induces some
of these enzymes and this may reduce the effect of concomitantly administered drugs.
Clinical observations suggest that oxcarbazepine does not induce these enzymes to the same
degree.
This study directly compares the ability of these two drugs to induce the cytochrome P450
3A4 enzyme, in healthy volunteers using a well defined biomarker reaction of a specific
enzyme activity.
It is the hypothesis that oxcarbazepine induces CYP3A4 to a lesser degree than
carbamazepine.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment