Metabolic Acidosis Clinical Trial
Official title:
The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations; Does Topiramat or Zonisamide Cause Metabolic Acidosis?
Verified date | November 2023 |
Source | Trakya University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The relationship of developing metabolic acidosis with antiepleptic drugs in craniotomy operations
Status | Completed |
Enrollment | 35 |
Est. completion date | August 15, 2023 |
Est. primary completion date | June 30, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Patients undergoing intracranial surgery with craniotomy and using antiepileptic drugs - ASA I-III - Patients undergoing elective surgery Exclusion Criteria: - Patients with a surgical procedure time of more than 5 hours - Patients who received more than 2 units of blood transfusion during the operation - Patients taking other drugs that can cause metabolic acidosis - Patients with diabetes mellitus, diabetes insipidus, hepatic or renal disease |
Country | Name | City | State |
---|---|---|---|
Turkey | Trakya University | Edirne | Centrum |
Lead Sponsor | Collaborator |
---|---|
Trakya University |
Turkey,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Preoperative Metabolic Acidosis | The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10. | Baseline | |
Primary | Intraoperative Metabolic Acidosis | The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10. | during the operation | |
Primary | Postoperative Metabolic Acidosis | The base deficit values in the preoperative, intraoperative and postoperative blood gases taken from the patients and the presence and severity of metabolic acidosis were evaluated. Metabolic acidosis severity was defined by base deficit levels: mild from -3 to -5, moderate from -5 to -10, and severe metabolic acidosis below -10. | Day 1 |
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