Intraoperative Cell Salvage and Postoperative Acidosis

Metabolic Acidosis Clinical Trial

Official title: The Contribution of Intraoperative Mechanical Red Cell Salvage to Acidosis in the Immediate Postoperative Period After Cardiac Surgery

Status Not yet recruiting

Clinical Trial Summary

Metabolic acidosis is a common complication that patients experience in the early postoperative period following cardiac surgery. Increasingly, the composition and volume of intravenous fluids administered during surgery have been implicated in the development of postoperative acidosis. Intraoperative Cell Salvage (ICS), an autologous blood transfusion technique employed by Cardiac/Perfusion Units to minimize blood loss during surgery, involves the infusion of of one such fluid, 0.9% sodium chloride. The rapid infusion of large volumes of 0.9% sodium chloride has previously been linked with the development of hyperchloraemic acidosis. We hypothesize that the volume of mechanically salvaged of red blood cells re-infused into patients undergoing heart surgery contributes to the acidosis that occurs in the early postoperative period.

To test this, we have designed an observational cohort study to check for correlation between the volume of cell salvaged blood infused during surgery and the severity of postoperative acidosis (which will be assessed using data from routine arterial blood gas samples).

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Acidosis
• Metabolic Acidosis

• NCT number: NCT02800343
• Study type: Observational
• Source: University of Edinburgh
• Contact: Peter R Alston, MBChB, FRCA
• Phone: +44 131 242 3180
• Email: peter.alston@ed.ac.uk
• Status: Not yet recruiting
• Phase: N/A
• Start date: July 2016
• Completion date: August 2016