Metabolic Acidosis Clinical Trial
— POKACIDOfficial title:
Incidence of Postoperative Ketosis and Metabolic Acidosis
The aim of this study is to define the incidence and nature of acidosis after major surgery using Figge's equations to directly measure acidosis. This study will also aim to compare the ability of indirect measures (base deficit, anion gap,corrected anion gap and lactate) to identify the presence of tissue acids in this population. The incidence of postoperative ketoacidosis as a contributor to tissue acidosis will be assessed through the use of point of care urinalysis.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | August 2013 |
Est. primary completion date | August 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients who have undergone major cancer surgery - Patients who have an arterial line in place - Patients who have a urinary catheter in place - Patients who will be admitted to intensive care following surgery - Adults >18 years - Adults who are capable of reading and understanding English Exclusion Criteria: - Patient refusal - Patients without an arterial line or urinary catheter in place - Patients receiving glucose / sliding scale insulin for management of diabetes mellitus |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United Kingdom | Royal Marsden NHS Foundation Trust | London | England |
Lead Sponsor | Collaborator |
---|---|
Royal Marsden NHS Foundation Trust |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Incidence of tissue acidosis, defined as tissue acids > 5mEq/L (Figge's equation) within one hour of completion of surgery | 31/08/13 | No | |
Secondary | Incidence of metabolic acidosis, defined by base deficit . 2 mEq/L (Henderson-Hasselback) within one hour of completion of surgery. | 31/08/13 | No |
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