Metabolic Acidosis Clinical Trial
Official title:
Perioperative Fluid Management in Patients Receiving Cadaveric Renal Transplants - Effects of Normal Saline Versus Balanced Infusates on the Incidence of Electrolyte and Acid-base Disturbances
Verified date | February 2013 |
Source | Medical University of Vienna |
Contact | n/a |
Is FDA regulated | No |
Health authority | Austria: Agency for Health and Food Safety |
Study type | Observational |
In this study we want to show that the choice of a balanced type fluid solution for the
perioperative fluid management of patients receiving cadaveric renal transplantation results
in less occurrence of intra- and postoperative hyperkalemia, and thus the need for
postoperative dialysis. Additionally, we aim to determine whether the use of a balanced
infusion solution leads to less occurrence of metabolic acidosis and electrolyte disorders
than the use of isotonic saline.
Furthermore we want to evaluate whether perioperative fluid management with balanced
infusion solutions results in a higher frequency of primary graft function than with
administration of isotonic saline.
We will test the hypothesis that the use of "Elomel isoton"(Fresenius Kabi Austria GmbH) a
balanced infusion solution will result in less occurrence of hyperkalemia and consequent
post-transplant dialysis, less occurrence of metabolic acidosis, decreased incidence of
electrolyte disorders and higher incidence of primary graft function when compared to
isotonic saline for perioperative fluid management in patients receiving cadaveric renal
transplantation.
Status | Completed |
Enrollment | 150 |
Est. completion date | February 2013 |
Est. primary completion date | February 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - All patients with end-stage-renal disease admitted for cadaveric renal transplantation will be included in the study Exclusion Criteria: - Patients younger than 18 years of age - Hyperkalemia defined as a serum potassium exceeding 5.5 mmol/L pre-operatively |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Austria | Medical University of Vienna/General Hospital of Vienna | Vienna |
Lead Sponsor | Collaborator |
---|---|
Medical University of Vienna |
Austria,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | intra or postoperative hyperkalaemia | 7 days | No | |
Secondary | metabolic acidosis | 7 days | No |
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04984226 -
Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD
|
Phase 2 | |
Completed |
NCT03317444 -
Evaluation of TRC101 in Subjects With Metabolic Acidosis Associated With Chronic Kidney Disease
|
Phase 3 | |
Recruiting |
NCT05582824 -
Lactate Metabolism in the Hypoperfused Critically Ill
|
||
Active, not recruiting |
NCT04010630 -
Sodium Bicarbonate for the Treatment of Severe Metabolic Acidosis With Moderate or Severe Acute Kidney Injury in ICU
|
N/A | |
Completed |
NCT02303548 -
Bicarbonate in Patients With Out-of-hospital Cardiac Arrest
|
Phase 2 | |
Recruiting |
NCT01860001 -
Incidence of Postoperative Ketosis and Metabolic Acidosis
|
N/A | |
Completed |
NCT01452412 -
Alkali Therapy in Chronic Kidney Disease
|
Phase 2/Phase 3 | |
Terminated |
NCT03710291 -
Evaluation of Effect of TRC101 on Progression of Chronic Kidney Disease in Subjects With Metabolic Acidosis
|
Phase 3 | |
Completed |
NCT02476253 -
Sodium Bicarbonate to Treat Severe Acidosis in the Critically Ill
|
Phase 3 | |
Completed |
NCT05940935 -
The Relationship of Developing Metabolic Acidosis With Antiepleptic Drugs in Craniotomy Operations
|
||
Withdrawn |
NCT03846258 -
High Versus Low Bicarbonate Bath in Critically-ill Patients Receiving Continuous Renal Replacement Therapy
|
Phase 4 | |
Completed |
NCT05970094 -
Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5
|
N/A | |
Recruiting |
NCT05784389 -
Reduction of Metabolic Acidosis in Patients With Chronic Kidney Disease in Stage 4 and 5
|
N/A | |
Terminated |
NCT04727528 -
Study of the Effect of SZC on Serum Potassium and Serum Bicarbonate in Patients With Hyperkalemia and Metabolic Acidosis Associated With Chronic Kidney Disease
|
Phase 3 | |
Completed |
NCT02098356 -
Comparison of High Versus Low Bicarbonate Hemodialysis
|
N/A | |
Recruiting |
NCT03897101 -
Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn)
|
||
Terminated |
NCT01894594 -
Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease
|
Phase 1 | |
Completed |
NCT01293266 -
Effect of Propofol and Sevoflurane on Lactate During Anesthesia for Pediatric Heart Catheterisation
|
N/A | |
Completed |
NCT01295190 -
Substitution of Propofol by Sevoflurane During Pediatric Cardiopulmonary Bypass
|
N/A | |
Completed |
NCT05147051 -
Meglimine Sodium Succinate for Correction of Metabolic Acidosis in Critically Ill Patients
|
Phase 2 |