Mesothelioma Clinical Trial
Official title:
Mesothelioma and Radical Surgery 2: a Multicentre Randomised Trial Comparing (Extended) Pleurectomy Decortication Versus no (Extended) Pleurectomy Decortication for Patients With Malignant Pleural Mesothelioma (Mars 2).
Mesothelioma is a cancer of the thin membrane that lines the chest and abdomen. Around 2500
people in the UK are diagnosed with mesothelioma each year and the median survival is
approximately 8.5 months. Exposure to asbestos is the most common cause although the cancer
does not usually become apparent until 40-60 years after exposure. Anti-cancer drugs
(chemotherapy) are usually given to help treat mesothelioma and sometimes lung-sparing
surgery (pleurectomy decortication) is undertaken. However, it is not known if this surgery,
in addition to chemotherapy, can increase survival and improve the quality of life for
patients. The aim of the MARS2 study is to compare surgery - (extended) pleurectomy
decortication - with no surgery with respect to overall survival, cost-effectiveness and
quality of life. Patients will be followed up by phone at regular intervals for 2 years.
Patients will be asked to complete and return a Quality of Life Questionnaire at these time
points.
MARS 2 also includes an optional 'Information study', where consenting patients may be
interviewed or have their consultations audio-recorded. The aim of the Information study is
to explore how a patient makes a decision to take part in research or not, with the overall
aim of improving recruitment to clinical trials.
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