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Phase II Study of Bevacizumab, Pemetrexed and Carboplatin as First-Line Therapy in Malignant Pleural Mesothelioma

Mesothelioma Clinical Trial

Official title:
Phase II Study of the Combination of Bevacizumab Plus Pemetrexed and Carboplatin as First-line Therapy in Patients With Malignant Pleural Mesothelioma

Clinical Trial Summary

The primary objective is to assess antitumor activity of the combination of bevacizumab, pemetrexed and carboplatin, in terms of time to progression.

Clinical Trial Description

Secondary endpoints are to evaluate:

- the objective response rate (RR) of the combination;

- the toxicity and the safety profile of the combination;

- the duration of response (RD) and time to treatment failure (TTF);

- the overall survival (OS)

- RR, TTP and OS according to baseline plasma VEGF levels (introduced with Amendment 1 dated 8/11/2007) ;

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00407459
Study type Interventional
Source Istituto Clinico Humanitas
Contact
Status Completed
Phase Phase 2
Start date September 2007
Completion date November 2010
View Details
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