Electrophysiological Biomarkers in MTLE Patients.

Mesial Temporal Lobe Epilepsy Clinical Trial

Official title:
Electrophysiological Biomarkers During Invasive Monitoring of Mesial Temporal Lobe Epilepsy Patients.

Status Terminated

Clinical Trial Summary

The investigators plan to enroll individuals with medical temporal lobe epilepsy who are undergoing surgical workup with clinically implanted intracranial electrodes. The study intends to administer computerized memory tasks and stimulation during the intracranial Electroencephalography (EEG) monitoring period.

Clinical Trial Description

This is a nonrandomized interventional trial that will apply brain stimulation via clinically implanted intracranial electrodes to subjects with medial temporal lobe epilepsy with the purpose of identifying biomarkers related to the pre-ictal state; to perform an acute parameter search to determine the stimulation pattern that most effectively modifies these biomarkers and to identify changes in memory (free recall) during asynchronous distributed multi-electrode stimulation (ADMES). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04710004
Study type	Interventional
Source	Emory University
Contact
Status	Terminated
Phase	N/A
Start date	November 30, 2021
Completion date	December 16, 2021

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See also
Status	Clinical Trial	Phase
Recruiting	`NCT06063850` - AMT-260 Gene Therapy Study in Adults With Unilateral Refractory Mesial Temporal Lobe Epilepsy	Phase 1/Phase 2
Recruiting	`NCT05608408` - PRIME: PReservIng Memory in Epilepsy	N/A
Completed	`NCT02383407` - Low Frequency Electrical Stimulation of the Fornix in Intractable Mesial Temporal Lobe Epilepsy (MTLE)	N/A