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Menopausal Sleep Fragmentation and Body Fat Gain

Menopause Clinical Trial

Official title:
Menopausal Sleep Fragmentation: Impact on Body Fat Gain Biomarkers in Women

Clinical Trial Summary

This study aims to investigate the impact of menopause-related sleep fragmentation on metabolic biomarkers of body fat gain. The investigators hypothesize that experimental sleep fragmentation will result in an adverse leptin response as a metabolic biomarker for body fat gain.

Clinical Trial Description

While obesity is highly prevalent in midlife and older women, with rates increasing markedly after age 40 and body fat increasing in half of women during and after the menopause transition, factors causing these changes are not well understood. Reduced total sleep time has been shown to adversely impact biomarkers of obesity, but the effect of the highly prevalent menopause-related sleep fragmentation secondary to hot flashes on metabolism and eating behaviors in humans is not known. We will use experimental paradigms to isolate the impact of menopause-related sleep disruption, as well as that of hot flashes and estrogen withdrawal, metabolic biomarkers of body fat gain and on eating behaviors, results of which will inform strategies to prevent body fat gain and improve cardio-metabolic health outcomes in women. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03047330
Study type Interventional
Source Brigham and Women's Hospital
Contact
Status Completed
Phase Phase 4
Start date July 15, 2017
Completion date August 1, 2022
View Details
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