Meningitis Clinical Trial
Official title:
Antibody Persistence and Response to Re-vaccination With Either Menactra® or Menomune® Vaccine Approximately Three Years Following Initial Vaccination in Adults Who Participated in Trial MTA29
The purpose of this trial is to describe antibody persistence and response to re-vaccination
with either Menactra® or Menomune® vaccine approximately three years following initial
vaccination in adults who participated in trial MTA29 (NCT00874549).
Objectives:
- To describe the rates of immediate reactions, solicited injection-site and systemic
reactions, all unsolicited adverse events, and serious adverse events following
vaccination.
- To evaluate persistence of serum bactericidal antibodies in subjects who received
Menactra® or Menomune® vaccine approximately three years ago.
- To evaluate the immune response to serogroups A, C, Y, and W-135 in subjects
re-vaccinated with either Menactra® or Menomune® vaccine.
Participants who were randomized and received either Menactra® or Menomune® vaccine in trial MTA29 will receive 1 dose of either Menactra® or Menomune®, respectively on Day 0 and will be followed-up for 28 days post-vaccination. ;
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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