AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas

Status Completed

Clinical Trial Summary

The goal of this clinical research study is to learn if the study drug AZD2014 can shrink growing or symptomatic meningiomas.

Clinical Trial Description

This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational intervention to learn whether the intervention works in treating a specific disease. "Investigational" means that the intervention is being studied. The goal of this clinical research study is to learn if the study drug AZD2014 can shrink growing or symptomatic meningiomas. Based on laboratory research, the cellular pathways which are blocked by AZD2014 are important for the growth and survival of meningiomas. Further treatment of meningioma cells in the laboratory setting has resulted in decreased survival of tumor cells. As such, the purpose of this research is to see whether treating your meningioma with AZD2014 will result in tumor shrinkage. The safety of AZD2014 will also be studied. Your physical state, your symptoms, changes in the size of the tumor, and laboratory findings obtained while on-study will help the research team decide if AZD2014 is safe and effective in patients with your condition. AZD2014 is being studied in patients with various cancers as a single agent (a drug that is used alone to treat the cancer) or in combination with a number of anticancer therapies. Previous studies have also allowed investigators to determine the best dose and frequency of AZD2014 to achieve anti-tumor effects while reducing the likelihood of side effects. The FDA (the U.S. Food and Drug Administration) has not approved AZD2014 as a treatment for any disease. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02831257
Study type	Interventional
Source	Massachusetts General Hospital
Contact
Status	Completed
Phase	Phase 2
Start date	August 31, 2016
Completion date	October 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04081701` - 68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.	Phase 4
Recruiting	`NCT03631953` - Combination of Alpelisib and Trametinib in Progressive Refractory Meningiomas	Phase 1
Completed	`NCT03273712` - Dosimetry-Guided, Peptide Receptor Radiotherapy (PRRT) With 90Y-DOTA- tyr3-Octreotide (90Y-DOTATOC)	Phase 2
Recruiting	`NCT04367779` - Research of Biomarkers of Response to Proton Beam Therapy in Pediatric and Adult Patients.
Withdrawn	`NCT00985036` - Vascular Endothelial Growth Factor (VEGF) Levels in Brain Tumor Patients	N/A
Completed	`NCT01347307` - Stereotactic Body Radiotherapy for Spine Tumors	N/A
Completed	`NCT01811524` - The Etiology and Progression of Brain Tumors	N/A
Completed	`NCT03648034` - Effects of Scalp Nerve Block With Ropivacaine on Postoperative Recovery Quality	N/A
Recruiting	`NCT06036706` - Neurocognitive Impact of Different Irradiation Modalities for Patients With Grade I-II Skull Base Meningioma:	N/A
Recruiting	`NCT06014905` - Feasibility of Acquiring Hyperpolarized Imaging in Patients With Meningioma	Phase 1
Not yet recruiting	`NCT04386642` - Tranexamic Acid Reduce Blood Loss in Meningioma Resection	Phase 4
Active, not recruiting	`NCT04595786` - The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection	N/A
Completed	`NCT04305470` - Gleolan for Visualization of Newly Diagnosed or Recurrent Meningioma	Phase 3
Completed	`NCT01967823` - T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Cancer	Phase 2
Not yet recruiting	`NCT02978677` - Proton Dose Escalation for Patients With Atypical or Anaplastic Meningiomas	N/A
Active, not recruiting	`NCT02933736` - Ribociclib (LEE011) in Preoperative Glioma and Meningioma Patients	Early Phase 1
Completed	`NCT02267928` - Information Presentation Formats	N/A
Completed	`NCT00589784` - Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma	Phase 2
Active, not recruiting	`NCT03071874` - Vistusertib (AZD2014) For Recurrent Grade II-III Meningiomas	Phase 2
Recruiting	`NCT05416567` - Embolization for Meningioma	N/A