Multisession Radiosurgery in Residual/Recurrent Grade II Meningiomas. — ATM  

Meningioma Atypical Clinical Trial

Official title: Hypofractionated Stereotactic Radiotherapy (Multisession Radiosurgery) in Residual/Recurrent Grade II Meningiomas: Feasibility Study.

Status Recruiting

Clinical Trial Summary

Fractionated radiosurgery will be delivered to atypical meningioma lesions in salvage setting for patients who present post-surgical residual lesion or develop recurrence.

Clinical Trial Description

Meningioma is the most common intracranial tumor (1). World Health Organization (WHO) grade II (atypical) meningioma recurs more frequently than WHO grade I (benign) meningioma, and patients with subtotally resected atypical meningioma should be treated with adjuvant radiation therapy (2). However, many atypical meningiomas can be gross totally resected, and whether to administer radiation to this population remains unclear. Apart from extent of resection, clinical characteristics such as age and gender and tumor-related characteristics such as tumor size and location have poor predictive capacity to determine which lesions will recur. The lack of professional consensus on the role of adjuvant radiation therapy (RT) derived from the heterogeneity and retrospective nature of the published data: standard fractionation fails to demonstrate a benefit in term of local control and survival. Recent advances in radiotherapy technology (staged radiosurgery) give the possibility to reach high dose levels only in tumor volume and in the same time to save the surrounding healthy tissues. The purpose of this study is to verify the related toxicity of a new radiotherapy protocol and as second end point to evaluate the efficacy on disease local control at 3 years. ;

Related Conditions & MeSH terms

• Meningioma
• Meningioma Atypical

• NCT number: NCT05081908
• Study type: Interventional
• Source: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
• Contact: Renato Mantegazza, MD
• Phone: +39022394
• Email: crc@istituto-besta.it
• Status: Recruiting
• Phase: N/A
• Start date: May 17, 2017
• Completion date: May 2023