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Clinical Trial Summary

Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders. This project aims to identify the how the choices individuals make influence what, and how, people remember by combining disparate techniques in computational modeling and direct brain recordings in human subjects. The researcher developed a dual-task paradigm, probing how decisions in one task affect immediate recognition memory. To examine the neural mechanisms underlying model-free RL's influence on memory, the researcher will record local field potential (LFP) and single neuron activity in various brain regions as epilepsy patients perform the proposed task. The results of this project will identify specific neurocomputational mechanisms unifying decision-making and memory processes.


Clinical Trial Description

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Study Design


Related Conditions & MeSH terms


NCT number NCT06072378
Study type Interventional
Source Icahn School of Medicine at Mount Sinai
Contact Salman E Qasim, PhD
Phone 212-824-9531
Email salman.qasim@mssm.edu
Status Recruiting
Phase N/A
Start date October 31, 2023
Completion date August 2025

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