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Dietary Flavanols and Dentate Gyrus Function

Memory Loss Clinical Trial

Official title:
Dietary Cocoa Flavanols and Age-Related Memory Decline

Clinical Trial Summary

to assess the effect of differing amounts of a cocoa-derived dietary flavanol (epicatechin ) on dentate gyrus function and corresponding cognitive function

Clinical Trial Description

In this double blinded trial, the participants, age 50-75 years, will be randomized to receive 0, 260, 510, or 770 mg daily* for 12 weeks and will be tested before and after the intervention. Cognitive testing will be conducted prior to randomization, and at weeks 4, 12, and 20 of the study.

In an optional substudy, fMRI (functional magnetic resonance imaging) with gadolinium contrast will be conducted to measure dentate gyrus function before randomization and then after completion of the 12-week intervention portion of the trial.

*see note in Record Log regarding the change in the method of assessment of cocoa flavanol content of the capsules ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02312310
Study type Interventional
Source New York State Psychiatric Institute
Contact
Status Completed
Phase N/A
Start date December 2015
Completion date April 2020
View Details
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