Clinical Trials Logo

Clinical Trial Details — Status: Active, not recruiting

Administrative data

NCT number NCT02499991
Other study ID # H2015:243
Secondary ID
Status Active, not recruiting
Phase N/A
First received July 10, 2015
Last updated May 9, 2016
Start date August 2015
Est. completion date August 2017

Study information

Verified date May 2016
Source University of Manitoba
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Research shows that there are a plenitude of interventions that can be used to enhance memory for older adults; however, the evidence as to whether these interventions enhance memory for daily activities is equivocal. The purpose of this pilot study is to test a memory intervention that is potentially useful in everyday life. Objectives of the pilot study are: 1) to examine the feasibility of the intervention (e.g., ease of use of materials provided); and 2) to gain preliminary evidence of the intervention's impact on recall of recent daily social events. Participants will be 20 cognitively healthy (i.e. not cognitively impaired) older adults, with 10 participants randomly assigned to either an intervention or control group, respectively. The study will consist of: a) a pre-training session; b) seven days of independent memory training; and c) a post-training session. The pre-training session will involve a test that measures recall of daily social events from the previous week. This will be followed by seven days of training for recall of daily social events. During the seven days, the intervention group will perform daily memory tasks using self-instructional materials given to them by the researcher, whereas the control group will use their own strategies for remembering social events that they are involved in during the week. The post-training session will occur after the seven days and will involve the same test as the pre-training session that measures recall of social events from the previous week. The hypotheses are that: a) recall of social events will be higher for the post-training test than in the pre-training test and; b) recall will be better for in the intervention group than the control group. The ease of use of the memory recall materials provided to the intervention group will be assessed in interviews.


Description:

Method Participants The sample will consist of 20 cognitively healthy older adults (aged 55 or older) recruited from the Centre on Aging participant database. The participant database has been approved by the Health REB (REB #HS14652). Individuals who are in the participant database have given their consent to be contacted by researchers about their willingness to participate in specific research projects. Names of individuals are provided to researchers by the Centre on Aging upon submission of REB approval and the research protocol.

Materials Questionnaires Pre-training Questionnaire - demographics. The questionnaire will consist of general questions about the participants. Items will include gender, age, and experience with memory training.

Pre-training memory recall test. The questionnaire will ask participants to describe social events they did during the previous week. This questionnaire will be given in the pre-training session.

Post-training memory recall test. The questionnaire will ask participants to describe social events they did during the previous week. This questionnaire will be given in the post-training session.

Post-training questionnaire. The questionnaire will ask participants about their thoughts regarding the format and usefulness of the instruction materials. For example, participants will be asked if they thought the study helped them remember social events.

Intervention group materials Memory tasks - instructions. This document instructs participants in the intervention group on how to use the memory tasks for daily social events.

Memory tasks - forms. Each day has a separate document that has a) a diary of social events; and b) tasks to review the week's social events.

Memory tasks - forms example. This is an example of the above form filled out to help explain how memory tasks are to be done.

Design This study involves an experimental design, whereby participants will be randomly assigned to one of two groups, an intervention group (n=10) and a control group (n=10). The independent variable is, therefore, the presence or absence of the daily memory recording task for social events. The dependent variables are: (a) the changes in performance on the written recall tests from pre- to post-training; and (b) the difference between the groups (i.e., Control vs. intervention group) on performance of memory of social events. Information about how useful the intervention materials were will be used in a more qualitative way to help improve the intervention.

Procedure The study will consist of: a) a pre-training session; b) seven days of independent memory training (intervention group) or usual way of remembering social events (control group); and c) a post-training session. The pre-training session will involve a test that measures recall of social events from the previous week. This will be followed by seven days of training for recall of daily social events. The post-training session will occur after the seven days and involve the same test as the pre-training session that measures recall of social events from the previous week.

Pre-training session. There will be separate pre-training sessions for each individual participant with the principal investigator either at the University of Manitoba (Bannatyne campus or Fort Garry campus) or, if participants prefers, in his or her own home. During the pre-training session, the principal investigator will provide an informed consent form to the participant. The principal investigator will describe the project, review the consent form and answer any questions. Once the participant provides written consent, a demographics questionnaire will be administered. A pre-training memory recall test will also be done that asks participants to list social events they did during the previous week.

Seven day training week. Materials will be provided to the intervention group during the pre-training session. Materials will include: a) instructions for memory tasks; b) forms for each day for diaries and tasks; and c) an example of the form filled out. The control group will not receive materials and will have to rely on their own memory strategies to remember social events during the 7 days.

Post-training session. There will be separate post-training sessions for each individual participant with the principal investigator either at the University of Manitoba (Bannatyne campus or Fort Garry campus) or in the participants' homes. A post-training memory recall test will be done that asks participants to list social events that they did on the previous week (i.e., this is the same test that was used in pre-training session). The post-training questionnaire will then also be administered to each participants.

Data Management Data will be entered into the computer. The computer file will not contain any names or addresses and each participant data will be identified by a unique participant ID only. Consent forms will be stored in a locked filing cabinet in Dr. Menec's research space (S112 Medical Services Bldg).

Analyses A total score of all social events recalled will be created. Scores will be calculated by the following scheme: a) one point for remembering an event; and b) one point for remembering the day of the event. Other scoring approaches will also be considered; for example, assigning a higher score if more detail about a person met is remembered. SPSS will be used to test hypotheses using two independent group t-tests. The use of t-tests is justified because a) the investigators can compare scoring on pre- and post-session memory recall tests; b) the investigators have an appropriate sample size of 20; and c) the investigators have two independent groups. The usefulness of the memory intervention materials will be examined more qualitatively by looking at responses to each of the questions and participants' comments.


Recruitment information / eligibility

Status Active, not recruiting
Enrollment 12
Est. completion date August 2017
Est. primary completion date August 2017
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 55 Years and older
Eligibility Inclusion Criteria:

- cognitively healthy

Exclusion Criteria:

- diagnosed cognition impairments such as Alzheimer's

Study Design


Related Conditions & MeSH terms


Intervention

Behavioral:
memory
keep track of social events in diary for memory recall. Used by treatment group

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
University of Manitoba

Outcome

Type Measure Description Time frame Safety issue
Primary Memory Recall Test (change from first session to second session i.e., 7 days later) The questionnaire will ask participants to describe social events they did during the previous week. First session, second session (7 days later from first session)
See also
  Status Clinical Trial Phase
Recruiting NCT03896529 - Neurobiological Mechanisms of Aging and Stress on Prospective Navigation N/A
Terminated NCT02331771 - Donepezil Memory Preservation Post ECT N/A
Recruiting NCT03268109 - COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old
Completed NCT00736034 - The Efficacy of Phosphatidylserine-Omega3 in Elderly Subjects With Memory Impairment Phase 4
Completed NCT04910399 - Development of an Innovative Health Ingredient From Marine By-products for the Healthy Aging N/A
Completed NCT02814526 - Exercise in Adults With Mild Memory Problems N/A
Recruiting NCT05289804 - Diminishing Accelerated Long-term Forgetting in Mild Cognitive Impairment Phase 1/Phase 2
Completed NCT04955457 - BDNF Promoter Methylation: Effects on Cognition, Stress and Anxiety and Depression Symptom in Healthy Women.
Completed NCT05033262 - Our Care Wishes - Dementia N/A
Recruiting NCT01919957 - Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies N/A
Not yet recruiting NCT01708200 - A Comparison of the Effectiveness of Two Types of Memory Training Programs in People With a Diagnosis of Mental Illness. N/A
Recruiting NCT04583215 - Enhancing Frontal Lobes Plasticity in Mild Cognitive Impairment N/A
Recruiting NCT05543681 - IGC-AD1 Trial on Agitation in Dementia Due to Alzheimer's Phase 2
Active, not recruiting NCT03205709 - Cognitive Training and Neuroplasticity in Mild Cognitive Impairment N/A
Recruiting NCT02302482 - Predictive Factors and Autonomy Level Change N/A
Completed NCT02301247 - Treating New Learning and Memory Deficits in Progressive Multiple Sclerosis (MS) N/A
Completed NCT01708304 - Reducing Disabilities in Alzheimer's Disease (RDAD) Translation in Area Agencies on Aging (AAAs) N/A
Recruiting NCT06025877 - Quality Improvement and Clinical Utility PrecivityAD2(TM) Clinician Survey
Recruiting NCT05122598 - Development and Evaluation of Computerized Olfactory Training Program for Cognitive Decline in Early Alzheimer's Disease Phase 2
Completed NCT04473235 - Better Memory With Literacy Acquisition Later in Life N/A