Memory Disorders Clinical Trial
— MEMOMORPHOfficial title:
Attention and Memory Disorders Related to Acute Morphine
The aim of the study is to determine if there are attention disorders related to acute
morphine use in single-traumatized patients and after that the investigators will determine
whether there are immediate memory problems associated with acute morphine withdrawal in
single-traumatized patients.
From a biochemical point of view, the analgesic effects of morphine and the central side
effects appear to be two different dimensions of the action of morphine, each related to a
metabolite. Regarding acute attention, it is difficult to differentiate attention deficit
disorder due to pain or due to morphine.
Two tests have been validated in the literature to evaluate attention and memory: the 15
words of Rey and the Stroop Color Word test. The investigators will use these two tests in
this study.
Status | Not yet recruiting |
Enrollment | 118 |
Est. completion date | November 2019 |
Est. primary completion date | November 2019 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patients over 18 - Mono traumatized (suspicion of bone fracture) without vital distress, neurological, cardio-circulatory or pulmonary involvement - Analgesia obtained, defined by a pain score on a numerical scale = 3/10 at the end of the treatment - Patient to be re-convened for plaster repair, control radiography or specialized consultation in the month following inclusion. - Patients presenting in an emergency department of Toulouse University Hospital Exclusion Criteria: - Patients with vital distress, whatever the cause, - Traumatized cranial, - pre-existing labeled attention disorders (eg, diagnosed hyperactivity), - Pre-existing memory disorders labeled (eg, dementia) - Use of opioid analgesics other than morphine in the care of these patients - Chronic opiate users (licit or illicit) - Psychiatric disorders - Acute alcohol poisoning, voluntary drug poisoning or not, acute intoxication by drugs - Visual disorders (colorblind ..), patients who can not read |
Country | Name | City | State |
---|---|---|---|
France | University Hospital Toulouse | Toulouse |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Toulouse |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The comparison of acute attention deficit according to the exposed or unexposed patient. | The primary endpoint selected is the comparison of acute attention deficit according to the exposed or unexposed patient. For each patient, the investigators will calculate the percentage of deficit between the Stroop Color Word test result at inclusion and at follow-up divided by the tracking score. This acute deficit is expressed as a percentage. The primary endpoint selected is the comparison of acute attention deficit according to the exposed or unexposed patient. |
1 month | |
Secondary | The comparison of the acute memory deficit according to the exposed or unexposed nature of the patient | The secondary endpoint chosen is the comparison of the acute memory deficit according to the exposed or unexposed nature of the patient. For each patient, the aim is to calculate the percentage of deficit between the test result of the 15 words of Reys test at inclusion and during the follow-up divided by the tracking score. This acute deficit is expressed as a percentage. |
1 month |
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