Tryptophan Supplementation to Improve Night Shift Workers' Health

Status Completed

Clinical Trial Summary

This randomized cross-over double-blinded trial aims to investigate the health effect of oral l-tryptophan supplementation on workers who rotate night shift work, and to examine the influences of different frequencies and timings of supplementation on the health effects.

Clinical Trial Description

This study aims to investigate the health effect of oral l-tryptophan supplementation on workers who rotate night shift work, and to examine the influences of different frequencies and timings of supplementation on the health effects. Night shift work affects melatonin and cortisol variation, insomnia, mood issues, and metabolic syndrome. Short-term tryptophan supplementation was shown to improve melatonin, sleep quality, and cortisol response to acute stress. Little is known whether a longer term of longer-term tryptophan supplementation would alleviate the health impacts of night shift work. Nevertheless, melatonin and cortisol have their normal circadian patterns. Nothing is known about what temporal structure of tryptophan supplement would maximize its health effects on night shift workers melatonin and cortisol levels. We will conduct a double-blind cross-over randomized controlled trial to examine the benefits of oral tryptophan administration (3g/day, t.i.d.) on night shift workers' health outcomes: melatonin and cortisol levels, sleep quality, moods and work performance. We expect to reveal the health effect of tryptophan supplementation in night shift workers by using sophisticated study design. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04505800
Study type	Interventional
Source	National Yang Ming University
Contact
Status	Completed
Phase	N/A
Start date	September 1, 2019
Completion date	December 31, 2020

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04044495` - Sleep, Rhythms and Risk of Alzheimer's Disease	N/A
Recruiting	`NCT06079853` - Nurse Suicide: Physiologic Sleep Health Promotion Trial	N/A
Completed	`NCT05017974` - Research on Improving Sleep During Pregnancy	N/A
Recruiting	`NCT05206747` - Ottawa Sunglasses at Night for Mania Study	N/A
Enrolling by invitation	`NCT04253054` - Chinese Multi-provincial Cohort Study-Beijing Project
Completed	`NCT04513743` - Ultra Long-Term Sleep Monitoring Using UNEEG™ Medical 24/7 EEG™ SubQ	N/A
Completed	`NCT03251274` - Bath Machine on Sleep Quality in Nursing Home	N/A
Completed	`NCT04102345` - Lavender vs Zolpidem Sleep Quality During Diagnostic PSG	Early Phase 1
Completed	`NCT03725943` - Comparison of Dreem to Clinical PSG for Sleep Monitoring in Healthy Adults	N/A
Active, not recruiting	`NCT05062161` - Sleep Duration and Blood Pressure During Sleep	N/A
Completed	`NCT04562181` - Consistency Evaluation of the qCON, qNOX Indices and Bispectral Index	N/A
Completed	`NCT05102565` - A Dyadic Telehealth Program for Alzheimer's Patients/Caregivers	N/A
Completed	`NCT05576844` - Ai Youmian (Love Better Sleep) for People Living With HIV	N/A
Completed	`NCT04688099` - Synovial Fluid Sleep Study
Recruiting	`NCT04171245` - Prescribing Laughter for Sleep and Wellbeing in UAE University Students	N/A
Completed	`NCT03758768` - The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms	N/A
Completed	`NCT03163498` - Evaluation of Sleep Pattern and Mood Profile in Hypertensive Patients
Completed	`NCT04093271` - Investigating the Efficacy of Rest-ZZZ Formula in Healthy Participants With Difficulty Falling Asleep or Staying a Sleep	Phase 1
Completed	`NCT03673397` - The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression	N/A
Completed	`NCT04120363` - Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations	Phase 4