Melasma Clinical Trial - Comparison Between Free Thyroxine & Thyroid

Status Completed

Clinical Trial Summary

The objective of the study was to compare the level of serum FT4 and TSH in patients with mild melasma and moderate-severe melasma. The determination of melasma lesion could also be known by using Janus II facial analysis UV light and polarization light to analyze the pattern of hyperpigmentation on melasma. This was a descriptive-analytic study used a cross-sectional method that was performed in 2019 at two different dermatology and venerology clinics in Indonesia, Cipto Mangunkusumo Hospital Jakarta and Gatot Subroto Army Hospital Jakarta. Forty-eight subjects with melasma, 50% diagnosed with mild melasma and 50% with moderate-severe melasma according to the modified melasma area and severity index (mMASI) score. The level of serum FT4 and TSH were then measured in both groups of the patients.

Clinical Trial Description

Melasma has been suspected to be linked with thyroid hormone. There is no study that explains the association of thyroid hormone level with melasma severity.

This study aims to find the difference in the levels of thyroid hormone in varying severity of melasma.

This was a descriptive-analytic study used a cross-sectional method that was performed in 2019 at two different dermatology and venerology clinics in Indonesia, Cipto Mangunkusumo Hospital Jakarta and Gatot Subroto Army Hospital Jakarta.

Forty eight patients participated in this study, 50% diagnosed with mild melasma and 50% with moderate-severe melasma. Subjects are chosen consecutively based on mMASI and Janus II measurement. The level of serum FT4 and TSH were then measured in both groups of the patients. The data is tabulated and a comparative analysis of serum FT4 and TSH levels with mild and moderate-severe melasma is done. In addition, this study also analyzes the level of serum FT4 and TSH with the result of Janus II facial analysis system scoring. The same method of analysis was done to know the association between mMASI and examination by using Janus II facial analysis system.

This study aims to find the difference in the levels of thyroid hormone in varying severity of melasma. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04359719
Study type	Observational
Source	Indonesia University
Contact
Status	Completed
Phase
Start date	July 15, 2019
Completion date	October 26, 2019

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05013801` - A Clinical Study to Evaluate the Effect of Facial Serum Q69 in Moderating the Appearance of Mild to Moderate Melasma	N/A
Recruiting	`NCT06174545` - Effectiveness and Safety of Pigment Solution Program (PSP) as Adjuvant Therapy in Melasma	N/A
Completed	`NCT01695356` - Ultraviolet and UV-Visible Light Photoprotection for the Treatment of Melasma	Phase 4
Recruiting	`NCT06278948` - Efficacy and Tolerability of Test Product Versus Cysteamine 5% in Treatment of Facial Epidermal Melasma	N/A
Not yet recruiting	`NCT05911698` - Fractional co2 Laser Followed by Either Vitamin c or Tranexamic Acid in Treatment of Melasma.	N/A
Recruiting	`NCT05656833` - Combination Topical Cysteamine and Fractional 1927nm Low-Powered Diode Laser for Treatment of Facial Melasma	N/A
Recruiting	`NCT04597203` - Efficacy and Safety of Using Combination of 755-nm Picosecond Alexandrite Laser and 2% Hydroquinone Compared With 2% Hydroquinone Alone for the Treatment of Melasma: a Randomized Split-face Controlled Trial	N/A
Completed	`NCT02138539` - Evaluation of an Herbal-Based De-Pigmenting System	Phase 4
Recruiting	`NCT01661556` - Clinical Trial of Hydroquinone Versus Miconazol in Melasma	Phase 4
Completed	`NCT01001624` - Melanil in the Treatment of Melasma	Phase 3
Terminated	`NCT03415685` - Lutronic PicoPlus Exploratory Clinical Trial	N/A
Recruiting	`NCT04765930` - Combined Q-switched Nd:YAG Laser and Platelet Rich Plasma Versus Q- Switched Nd:YAG Laser Alone in Melasma	N/A
Completed	`NCT04137263` - Study Evaluating the Efficacy of DOSE Formulations in Treating Melasma and Cutaneous Signs of Aging	N/A
Recruiting	`NCT03686787` - Oral Tranexamic Acid and Laser for Treatment of Melasma	Phase 4
Completed	`NCT05969587` - Cysteamine Compared to Hydroquinone in Melasma	Phase 3
Completed	`NCT00472966` - Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma	Phase 4
Completed	`NCT00500162` - Comparison of Two Tri-Luma® Maintenance Regimens in the Treatment of Melasma	Phase 4
Completed	`NCT05884151` - Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of Melasma	Phase 1
Completed	`NCT05887219` - Comparison of Azelaic Acid 20 % Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in Melasma	Phase 1
Recruiting	`NCT03308370` - Platelet Rich Plasma in Treatment of Melasma	Phase 3

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Comparison Between Free Thyroxine and Thyroid Stimulating Hormone Levels on Melasma Severity

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms