Melasma Clinical Trial
Official title:
A Clinical Usage Study to Evaluate the Safety and Efficacy of an Herbal-Based De-Pigmenting System
Verified date | November 2015 |
Source | Sadick Research Group |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to evaluate the effectiveness and tolerability of an herbal de-pigmenting regimen applied to one side of the face compared with hydroquinone applied to the other side of the face in treating mottled hyperpigmentation and melasma.
Status | Completed |
Enrollment | 28 |
Est. completion date | October 2014 |
Est. primary completion date | October 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 30 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Female age 30-65 - Must be in good general health - Must be willing to use sunscreen on the face daily - Must be willing to avoid tanning beds and excessive exposure to direct sunlight - Must be willing to continue using regular cosmetic regimen Exclusion Criteria: - Nursing pregnant/ planning to become pregnant during the course of the study - Using a medication that increases sensitivity to sunlight including doxycycline, minocycline, tetracycline, ciprofloxin, hydrochlorothiazide, and sulfonamides. - Any known allergies/sensitivities to facial skincare products, anti-aging products, de-pigmenting products, or products containing hydroquinone - Usage of any new skincare products during the course of the study - Presence of atopic dermatitis or psoriasis on the face - Uncontrolled diabetes, hypertension, hypothyroidism, hyperthyroidism - TCA or other deep peels within 1 year or medium to light peels within 3 months prior to starting the study - Facial/laser treatment within the last 3 months - Facial cosmetic surgery within the last 12 months - Use of product, topical, or systemic medication, known to affect dyschromia, having "whitening" or anti-aging properties - Physical skin conditions such as excessive hair, scarring, tattoos that might impair evaluations of the test sites - Active hepatitis, immune deficiency, or autoimmune disease |
Country | Name | City | State |
---|---|---|---|
United States | Sadick Research Group | New York | New York |
Lead Sponsor | Collaborator |
---|---|
Sadick Research Group | Episciences, Inc. |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Melanin Index | The melanin index of the skin will be measured at baseline and at each follow-up visit with a non-invasive device. At the end of the study, the change of the Melanin index over a period of 6 months will be calculated. | 6 months | |
Secondary | Irritation | Both objective irritation (erythema, edema, peeling, scaling/dryness) and subjective irritation (burning/stinging, itching, dry/tight feeling) will be measured at each visit via visual grading assessments and subject questionnaires. | Baseline, 1 month, 2 month, 4 month, 6 months |
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