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Melanoma clinical trials

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NCT ID: NCT03512457 Completed - Melanoma Clinical Trials

Skin Self-Examination Education During Mammography

SSE
Start date: May 30, 2018
Phase: N/A
Study type: Interventional

The skin self-examination for melanoma (SSE) educational materials were developed with the input provided by women undergoing screening mammograms. The investigators seek to evaluate the performance of SSE by women and find out if women seek care with a dermatologist for a concerning mole or for a melanoma screening examination by a dermatologist after reviewing the materials received during the mammogram visit. The purpose of this study is to enhance the early detection of melanoma among women who are engaging in health promotion by having mammograms. The investigators specifically aim to evaluate the performance of SSE by women, who receive information during their mammogram appointment, and then follow-up with dermatology for a melanoma screening examination.

NCT ID: NCT03511391 Completed - Clinical trials for Non-small Cell Lung Cancer

CHEckpoint Inhibition in Combination With an Immunoboost of External Beam Radiotherapy in Solid Tumors

CHEERS
Start date: March 9, 2018
Phase: Phase 2
Study type: Interventional

This randomized controlled phase II trial will investigate whether the addition of stereotactic body radiotherapy to checkpoint inhibitor treatment in patients with non-small-cell lung carcinoma, urothelial carcinoma, renal cell carcinoma, melanoma or head-and-neck carcinoma can improve progression-free survival as compared to checkpoint inhibitor monotherapy. The primary outcome is progression-free survival; secondary outcomes include overall survival, response according to iRecist and Recist v1.1 and toxicity.

NCT ID: NCT03509467 Completed - Melanoma (Skin) Clinical Trials

Using MC1R Genotype to Impact Melanoma Risk Behavior

Start date: August 3, 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to examine how different messages about risk of melanoma can impact the way people protect themselves against developing these diseases.

NCT ID: NCT03508297 Completed - Melanoma (Skin) Clinical Trials

Reflectance Confocal Microscopy to Diagnose MM & LM

Start date: March 14, 2017
Phase:
Study type: Observational

A reflectance confocal microscope is a machine which is able to examine the upper layers of the skin painlessly and without the need for taking a biopsy. We would like to examine the images taken by the confocal microscope to see if it can help more accurately identify lesions which are worrying rather than a benign mole. We are performing this study in patients in whom we have recommended excising a mole to exclude a cancer. If the results of the study show that the confocal microscope can help more accurately diagnose Melanomas then this would reduce the number of biopsies that are taken that turn out not to be cancerous (ie unnecessary biopsies).

NCT ID: NCT03504696 Completed - Melanoma Clinical Trials

Effectiveness, Safety and Use of Nivolumab Administered During the French Temporary Authorization for Use in Patients With Advanced Melanoma

Start date: December 20, 2016
Phase:
Study type: Observational

This study will be conducted with the aim of estimating the effectiveness, safety, patterns of use of nivolumab, and characteristics of patients with unresectable or metastatic melanoma, treated with nivolumab monotherapy in the ATU setting.

NCT ID: NCT03484923 Completed - Melanoma Clinical Trials

Study of Efficacy and Safety of Novel Spartalizumab Combinations in Patients With Previously Treated Unresectable or Metastatic Melanoma

PLATforM
Start date: September 10, 2018
Phase: Phase 2
Study type: Interventional

The primary purpose of this study is to evaluate the efficacy of novel spartalizumab (PDR001) combinations in previously treated unresectable or metastatic melanoma

NCT ID: NCT03472027 Completed - Melanoma Clinical Trials

Phase I Study of BCD-145 (Anti-CTLA-4) in Patients With Unresectable/Metastatic Melanoma

Start date: October 2, 2017
Phase: Phase 1
Study type: Interventional

A Multicenter Open-Label Single-Arm Multi-Cohort Phase I Study of Pharmacokinetics, Pharmacodynamics, Safety, and Immunogenicity of BCD-145 (JSC BIOCAD, Russia) Monotherapy in Patients with Unresectable/Metastatic Melanoma.

NCT ID: NCT03450876 Completed - Melanoma Clinical Trials

Long Term Quality of Life in Melanoma Patients in Netherlands

Start date: December 15, 2016
Phase:
Study type: Observational

Study of late physical, psychological and social effects in patients treated with ipilimumab for advanced (stage IV or unresectable stage III) melanoma.

NCT ID: NCT03448497 Completed - Melanoma Clinical Trials

Study of First-line Treatment Patterns and Clinical Outcomes in Patients With Advanced Melanoma in the United Kingdom

Start date: December 14, 2017
Phase:
Study type: Observational

The purpose of this study is to describe the first-line therapy landscape for patients with advanced melanoma and to describe clinical outcomes and healthcare resource utilization in a subset of treatment-naïve patients who initiated nivolumab + ipilimumab combination therapy.

NCT ID: NCT03438279 Completed - Melanoma Clinical Trials

Survival Study for Participants Treated With Ipilimumab-Nivolumab Combination Therapy

Start date: June 23, 2015
Phase: N/A
Study type: Observational

This study will review published trial literature and documents for Overall Survival (OS) to evaluate the association between the hazard of death and each baseline variable.