Intense Pulsed Light in Meibomian Gland Dysfunction

Status Recruiting

Clinical Trial Summary

Meibomian gland dysfunction (MGD) is a major cause of dry eye disease (DED). Up to 86% of patients suffering from DED also show signs of MGD. Traditional treatment of MGD is based on eye lid hygiene and massage in combination with intensive usage of lubricants. Recently, a novel technology the intense pulsed light (IPL) therapy was introduced, which shows promising results in patients with meibomian gland dysfunction. Originating from field of dermatology, subjecting improvement of dry eye symptoms was recognized after the treatment of facial rosacea using IPL. Different hypotheses exist how IPL treatment might improve the situation in the dry eye patient. Warming of the eyelid, due to the light application and reduction of bacterial load are two possible mode of actions. Further, the used wavelengths in IPL may be modified that the light is only absorbed by oxygenated haemoglobin, which lead to an obliteration of telangiectasia and reduced inflammation on the lid margin. This principal is applied in the treatment of facial rosacea. Aim of this study is to investigate the effect of IPL therapy in patients with MGD on dry eye parameters as well as subjective complaints.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Meibomian Gland Dysfunction

Clinical Trial Details

NCT number	NCT05089591
Study type	Interventional
Source	Vienna Institute for Research in Ocular Surgery
Contact	Stefan Palkovits, MD, PhD
Phone	+43 (0)1 91021- 57564
Email	office@viros.at
Status	Recruiting
Phase	N/A
Start date	October 20, 2021
Completion date	November 1, 2022

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05062564` - Efficacy of LipiFlow in Patients Affected by Meibomian Gland Dysfunction in Reducing Post-cataract Surgery Dry Eye	N/A
Completed	`NCT04884243` - Safety, Efficacy and Pharmacokinetics of CBT-006 in Patients With Meibomian Gland Dysfunction	Phase 2
Active, not recruiting	`NCT04425551` - Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction	N/A
Terminated	`NCT02596919` - Fast Infrared Meibography (Photography)	N/A
Completed	`NCT01207752` - The Efficacy of an Ocular Emulsion in Meibomian Gland Dysfunction	N/A
Completed	`NCT05162261` - to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysfunction	N/A
Recruiting	`NCT06064071` - Clinical Study Evaluating Nordlys™ SWT IPL for Dry Eye Disease (DED) Due to MGD	N/A
Completed	`NCT03652051` - A Multicenter Study Evaluating AZR-MD-001 in Patients With Meibomian Gland Dysfunction and Evaporative Dry Eye Disease (DED)	Phase 2
Recruiting	`NCT03767530` - Efficacy and Safety of Thermic Devices in the Treatment of Meibomian Gland Dysfunction	N/A
Active, not recruiting	`NCT05577910` - Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress Therapies for MGD	N/A
Completed	`NCT04889950` - Clinical Study to Evaluate the Safety and Effectiveness of The Tixel Fractional System in the Treatment of Meibomian Gland Disfunction	N/A
Recruiting	`NCT06004895` - Mechanisms of Light-based Therapies for Dry Eye Disease	N/A
Completed	`NCT04147962` - Intense Pulsed Light in Meibomian Gland Dysfunctions
Completed	`NCT02256969` - Intraductal Meibomian Gland Probing Trial	Phase 4
Completed	`NCT04500821` - Evaluation of the LipiFlow System With a New Activator	N/A
Completed	`NCT03318874` - Optimization of the Treatment of Dry Eye Disease Caused by Meibomian Gland Dysfunction	Phase 4
Completed	`NCT06278584` - iLux Treatment for Meibomian Gland Dysfunction	N/A
Recruiting	`NCT04052841` - Morphological Analysis of Meibomian Glands	N/A
Completed	`NCT05028491` - The Influence of Meibomian Gland Expression on Corneal Aberrations in MGD Patients
Completed	`NCT03617315` - Crosslinked Hyaluronic Acid With Liposomes and Crocin in Dry Eye	N/A