Dry Eye Clinical Trial
Official title:
Prospective Study of the Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction
The modern treatment of meibomian gland dysfunction(MGD) is based on anti-inflammatory drops
or oral antibiotics for decreasing dry eye disease (DED) associated inflammation, warm
compresses for liquefying the thicker meibum, and lid hygiene for reducing the bacterial
overload. But, such treatments have shown limited effectiveness to a large proportion of
patients with MGD, due to the multifactorial background of the disease. Thus, alternative
approaches aiming at different aspects of the DED pathophysiology are needed.
Elimination of posterior lid-margin hyperemia with telangiectasia could be a treatment target
for reducing the secretion of inflammatory mediators in the course of MGD. Using the
mechanism of photocoagulation via selective thermolysis, laser light could contribute to the
destruction of abnormal vessels at the posterior lid-margin and thus, the reduction of
inflammation. Recently, sub-threshold (micropulse) laser photocoagulation was introduced in
ophthalmology and offers significant clinical advantages compared to conventional continuous
wave (CW) approach, preventing laser induced thermal damage and related treatment side
effects.
This study investigates the effect of sub-threshold (micropulse) laser treatment for dry eye
disease due to meibomian gland dysfunction combined with increased eyelid margin vascularity.
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