Clinical Trials Logo

Clinical Trial Summary

The purpose of this study:(1) Development of a new risk classification model for childhood medulloblastoma. (2) Evaluation and improvement of existing individualized treatment protocols.


Clinical Trial Description

Medulloblastoma (medulloblastoma, MB) is the most common intracranial malignant tumor in children, accounting for 20% of all central nervous system tumors in children, seriously affecting the quality of life and life span of children. Based on a retrospective analysis of previous MB cases in our center, we found that the clinical prognosis of previous MB patients in our center was worse than that in foreign countries, with an overall five-year survival rate of about 65%, and nearly 30% of the patients had tumor recurrence and metastasis within 2 years after the operation, and the prognosis was poor. We analyzed the possible reasons as follows: (1) the compliance to radiotherapy and chemotherapy in children with MB in our center was poor, and some of the patients only completed radiotherapy and had poor compliance with chemotherapy; (2) due to the lack of family doctor system, the tumor of the newly diagnosed patients was huge, which seriously affected the important brain function and clinical prognosis; (3) the patients were not followed up strictly and regularly after operation to monitor tumor recurrence, which led to poor treatment effect after recurrence. (4) the unified treatment standard has not been formed yet, and the treatment mode for patients is complex. As the largest neurosurgery and pediatric neurosurgery center in China, the center intends to prospectively establish a high-quality homogeneous MB observation cohort in children, make use of the center's case resources and biological sample processing advantages, and carry out accurate treatment research on children's MB through regular follow-up and systematic management of the clinical cohort. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05406947
Study type Observational
Source Beijing Tiantan Hospital
Contact yongji TIAN, MD
Phone 15801593549
Email tianyongji@bjtth.org
Status Not yet recruiting
Phase
Start date January 30, 2023
Completion date December 31, 2030

See also
  Status Clinical Trial Phase
Terminated NCT04167618 - 177Lu-DTPA-Omburtamab Radioimmunotherapy for Recurrent or Refractory Medulloblastoma Phase 1/Phase 2
Active, not recruiting NCT03288168 - Children's and Adolescents' Medulloblastoma Molecular Subgroups in China
Recruiting NCT05298995 - GD2-CAR T Cells for Pediatric Brain Tumours Phase 1
Recruiting NCT04174820 - Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition
Completed NCT04860934 - Dual Task Training On Children With Ataxia After Medulloblastoma Resection N/A
Active, not recruiting NCT06193759 - Immunotherapy for Malignant Pediatric Brain Tumors Employing Adoptive Cellular Therapy (IMPACT) Phase 1
Suspended NCT03904862 - Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery Phase 1/Phase 2
Withdrawn NCT01697514 - A Study of LY2940680 in Pediatric Medulloblastoma or Rhabdomyosarcoma Phase 1
Recruiting NCT05230758 - Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour Phase 3
Completed NCT02238899 - Multicenter Register for Children and Young Adults With Intracranial Localized Medulloblastoma, CNS-PNET or Ependymoma N/A
Recruiting NCT05057702 - Individualized Treatment Plan in Children and Young Adults With Relapsed Medulloblastoma N/A
Recruiting NCT04185038 - Study of B7-H3-Specific CAR T Cell Locoregional Immunotherapy for Diffuse Intrinsic Pontine Glioma/Diffuse Midline Glioma and Recurrent or Refractory Pediatric Central Nervous System Tumors Phase 1
Completed NCT04528316 - Physical Activity on Postural Stability and Coordination in Children With Posterior Fossa Tumor N/A
Terminated NCT02624388 - Study of Genistein in Pediatric Oncology Patients (UVA-Gen001) Phase 2