Clinical Trials Logo
  1. Home
  2. Mechanical Power
  3. NCT05962125

The Role of Periodic Alveolar Recruitment Maneuvers in Intraoperative Protective Ventilation — REMAIN-2  

Postoperative Pulmonary Complications Clinical Trial

Official title:
Effects of Three Open-lung Strategies on Respiratory Function and Lung Injury in Protective Ventilation for Laparoscopic Anterior Resection: a Randomized Controlled Trial

Clinical Trial Summary

The goal of this clinical trial is to compare three open-lung strategies on respiratory function and lung injury in protective ventilation for laparoscopic anterior resection. It aims to answer whether a periodic alveolar recruitment maneuvers (PARM) strategy alone was an appropriate open-lung strategy in intraoperative protective ventilation. Patients were randomly assigned (1:1:1) to receive one of three open-lung strategies in protective ventilation: PARM alone (alveolar recruitment maneuvers [ARM] repeated every 30 min), positive end-expiratory pressure (PEEP) alone (a PEEP of 6 to 8 cm H2O), or a combination of PEEP and PARM (a PEEP of 6 to 8 cm H2O combined with ARM repeated every 30 min). The primary outcome is the mechanical power before the end of intraoperative mechanical ventilation. Secondary outcomes included the accumulative intraoperative mechanical power, an arterial partial pressure of oxygen (PaO2) / inhaled oxygen concentration (FiO2) ratio (P/F ratio) before the end of intraoperative mechanical ventilation, the rates of respiratory failure at post-anesthesia care unit (PACU) and three postoperative days, the concentration of soluble advanced glycation end products receptor (sRAGE) and Clara cell protein 16 (CC16) at the end of surgery, postoperative pulmonary complications score, postoperative hospitalization days and so on.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05962125
Study type Interventional
Source Sixth Affiliated Hospital, Sun Yat-sen University
Contact
Status Completed
Phase N/A
Start date August 21, 2023
Completion date December 31, 2023
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT06021249 - Comparing Innovative and Traditional Ventilation Strategies on Atelectasis and Prognosis in Elderly Patients N/A
Not yet recruiting NCT06023017 - The Effect of Preoperative Prone Position Training on PPCs in Patients Undergoing Laparoscopic Sleeve Gastrectomy N/A
Active, not recruiting NCT06304779 - The Effect of Continuous Intravenous Infusion of Lidocaine on PPCs and Prognosis in Emergency Surgical Patients With IAI N/A
Completed NCT03688724 - Perioperative Diaphragm Point of Care Ultrasound
Not yet recruiting NCT05519657 - Incidence and Risk Factors of PPCs in Elderly Patients Undergoing Robot Assisted Laparoscopic Pelvic Surgery
Recruiting NCT06150079 - Individualized PEEP Titration on Postoperative Pulmonary Complications N/A
Completed NCT04605250 - Respiratory Variability for Respiratory Monitoring During the Postoperative Recovery Period N/A
Not yet recruiting NCT02732574 - Oscillating Positive Expiratory Pressure (OPEP) Therapy in High Risk Patients Following Cardiac Surgery N/A
Not yet recruiting NCT05830474 - Effect of Continuous Intra-airway Monitoring Under Visible Double-lumen Bronchial Catheter on Postoperative Complications of Lung Surgery N/A
Completed NCT05401253 - The Association of Different Levels of Physical Activity on Postoperative Pulmonary Complications in Patients Undergoing Thoracoscopic Lung Resection Surgery
Not yet recruiting NCT06304493 - REMINDers for Incentive Spirometry in PACU (REMIND-IS in PACU) N/A
Completed NCT02918877 - Anesthetics to Prevent Lung Injury in Cardiac Surgery Phase 1/Phase 2
Not yet recruiting NCT06396767 - Diaphragmatic Inspiratory Amplitude as a Prognosticator for Postoperative Pulmonary Complications After Cardiac Surgery
Recruiting NCT04408495 - Intraoperative Mechanical Ventilation and Postoperative Pulmonary Complications After On-pump Cardiac Surgery in High-risk Patients N/A
Recruiting NCT05515809 - Evaluation of the Effect of Para-sternal Block on Postoperative Respiratory Function After Cardiac Sternotomy Surgery Phase 3
Recruiting NCT05922449 - Using Thoracic Paravertebral Block for Perioperative Lung Preservation During VATS Pulmonary Surgery N/A
Recruiting NCT04108130 - An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study N/A
Not yet recruiting NCT05701449 - Prevention and Treatment of Perioperative Lung Injury in Elderly Patients
Not yet recruiting NCT05671952 - Multi-center Study on Reducing Postoperative Pulmonary Complications in Elderly Patients N/A
Not yet recruiting NCT05671939 - Different Algorithm Models to Predict Postoperative Pulmonary Complications in Elderly Patients