Maternal Obesity Clinical Trial
Official title:
Evaluation of B. Bifidum 900791 as a Modulator of Microbiota, Inflammatory Mediators and Metabolic Hormones in Breast Milk From Obese Mothers
Human breast milk harbours a specific microbiota including bacteria from the Lactobacillus
and Bifidobacterium genera, that contribute to the bacterial colonization of the infant gut
in the post-natal period. An entero-mammary pathway has been suggested by which selected
bacteria from the maternal gut would be transmitted to the mammary gland through dendritic
cell trafficking by the lymphatic pathway. Accordingly, some studies have detected the
presence of probiotic strains in breast milk from mothers who were consuming them. The
administration of probiotic supplements to lactating mothers has also been shown to modulate
milk concentrations of inflammatory markers and metabolic hormones, impacting positively the
infant health. Noteworthily, many of these inflammatory and hormonal biomarkers are altered
in the breastmilk from pre-pregnancy obese mothers, compared with these who were
normal-weight, possibly affecting the infant health. It is unclear whether the breast milk
microbiota of obese mothers is altered and the impact of probiotic administration on the
breastmilk microbiota and on the normalization of breastmilk alterations in obese mothers is
unknown.
Based on these antecedents, the aim of this study is to determine if the administration of a
B. bifidum 900791-containing foodstuff to mothers during the perinatal period normalizes the
breast milk concentrations of interleukin (IL)-6, C-Reactive Protein (CRP), insulin,
adiponectin and resistin, and the microbiota of obese mothers, compared with normal-weight
mothers.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00530439 -
Lifestyle and Pregnancy: The Clinical Effect of Lifestyle Intervention During Pregnancy in Obese Women
|
N/A | |
| Not yet recruiting |
NCT06245083 -
Evaluating Pyrroloquinoline Quinone (PQQ) for Improving Obese Pregnancy Outcomes
|
Early Phase 1 | |
| Recruiting |
NCT03084120 -
Effect of the Maternal Obesity and/or the By-pass on the Growth and the Nutritional Balance of the Child
|
N/A | |
| Recruiting |
NCT05207059 -
Healthy Early Life Moments in Singapore
|
N/A | |
| Terminated |
NCT03435458 -
Balloon to Induce Labor in Generous Women.
|
Phase 3 | |
| Not yet recruiting |
NCT05986539 -
Early Life Feeding Exposure and Infant Immune and Health Status.
|
||
| Not yet recruiting |
NCT06179381 -
Feeding the fAmiLy: the Intergenerational approaCh to fIght obesiTY (FACILITY)
|
||
| Completed |
NCT05475951 -
Gasdermin-D and Pannexin-1 in Pregnancy
|
N/A | |
| Active, not recruiting |
NCT04060381 -
Myocardial Deformation Before and After Birth
|