RCT to Evaluate Biocompatibility of Resin-based Dental Materials

Materials Testing Clinical Trial

Official title: Randomized Clinical Trial in Children to Evaluate the Biocompatibility of Resin-based Dental Materials

Status Not yet recruiting

Clinical Trial Summary

In this randomized clinical trial, the bio-compatibility of 2 materials used for dental restorations will be compared: glass-ionomer vs resin-based composites.

Urine and saliva samples will be taken for determination of bisphenol A levels at several time points, and for analysis of the estrogenic activity using ERE-CALUX.

Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit. Global alterations in DNA methylation and DNA hydroxymethylation levels will be determined using UPLC-MS/MS.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Health Services Research

Related Conditions & MeSH terms

• Materials Testing

• NCT number: NCT02874625
• Study type: Interventional
• Source: Universitaire Ziekenhuizen Leuven
• Status: Not yet recruiting
• Phase: N/A
• Start date: January 2017