Recurrent Mantle Cell Lymphoma Clinical Trial
Official title:
Impact of Intervention With Deferasirox on the Immune Function of Patients With Hematologic Diseases and Transfusion-Related Iron Overload
RATIONALE: Deferasirox may remove excess iron from the body caused by blood transfusions.
PURPOSE: This clinical trial studies deferasirox in treating iron overload caused by blood
transfusions in patients with hematologic malignancies.
PRIMARY OBJECTIVES: I. To determine the effects of the iron-chelating agent deferasirox on
changes in: neutrophil function; macrophage function; lymphocyte function.
SECONDARY OBJECTIVES: I. To determine the effect of chelation on the incidence of bacterial,
viral and fungal infections documented by clinical, microbiologically-proven versus
radiologically-proven criteria. II. To determine the effect of iron chelation on mortality
and morbidity with incidence of the following parameters: Need for hospitalization; Duration
of hospitalization; Need for ventilatory support; Need for exchange transfusion/apheresis;
Need for treatment with antifungals or antibiotics for documented infections.
OUTLINE: Patients receive oral deferasirox once daily for up to 6 months or until blood
counts recover in the absence of disease progression or unacceptable toxicity.
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