Hemorrhage Clinical Trial
Official title:
Observational Study to Assess the Safety and Clinical Effectiveness of the Hospital Universitario de Canarias Massive Transfusion Protocol
Massive haemorrhage is defined as the necessity of 3 or more packed red blood cells in one
hour, the transfusion of 10 packed blood cells, the loss of the half of the blood volume,
the loss of 4-5 cc/kg/h or more, and haemorrhage shock.
Haemorrhage shock provokes changes in the bloodstream with celular and organic disfunction.
In many cases massive transfusion is needed to stabilize the vital function. This massive
transfusion can have serious side effects (infectious and immunologic and no immunologic
reactions) and increase the morbidity and mortality.
Massive transfusion protocols improve the survival in severe trauma injury patients. The
transfusion of fixed rate of packed red blood cells, fresh frozen plasma and platelet
concentrates have decreased the severity of trauma induced coagulopathy.
Recently several studies have shown the benefit of massive transfusion protocols with high
transfusion ratios (1:1:1 RBC:FFP:PLT) in mortality after severe trauma. So early and
aggressive transfusion improve the outcomes and the resources.
Massive Transfusion Protocol have been elaborated in the Hospital Universitario de Canarias
with high transfusion ratios (1:1:1 RBC:FFP:PLT) . The goals of this protocol is to reduce
the variability in the clinic experience, to reduce the transfusion necessities and to
assure an safe treatment with blood products.
So with this study the investigators will evaluate if the goals of this Protocol are
followed and if the use of this Protocol is really safe and efficient.
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