Marijuana Smoking Clinical Trial
Official title:
Behavioral Economic Analysis of Demand for Marijuana
Verified date | February 2024 |
Source | Brown University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This laboratory study will employ a multi-session experimental design to examine the behavioral economic demand for marijuana, by studying effect of marijuana administration (High THC) on demand for marijuana, and marijuana smoking topography. The study will recruit 100 non-treatment seeking marijuana users who smoke marijuana at least twice weekly.
Status | Completed |
Enrollment | 133 |
Est. completion date | May 24, 2021 |
Est. primary completion date | May 24, 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - marijuana use at least 8 times in the past month on average and at least monthly for the past 6 months - English-speaking - negative urine toxicology screen for drugs other than marijuana - non-treatment seeking - purchase of marijuana at least twice in the past 6 months to confirm familiarity with the construct to be measured Exclusion Criteria: - positive pregnancy test - nursing - inability to use contraception during the study - poor physical health - positive breath alcohol concentration - diagnosis of a current affective disorder, psychosis, and panic disorder - self-report of past serious adverse reaction to marijuana - current psychotropic drug use - smoking more than 20 tobacco cigarettes per day - inability to abstain from marijuana for 15 hours - body mass index outside 18.5-30 kg/m2 range |
Country | Name | City | State |
---|---|---|---|
United States | Brown University | Providence | Rhode Island |
Lead Sponsor | Collaborator |
---|---|
Brown University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Validity of the Marijuana Purchase Task (MPT) | The Marijuana Purchase Task will be used to collect data on marijuana demand. Participants indicate how much marijuana they would purchase at varying levels of price (e.g., free - $60). Indices of marijuana demand are derived from the task and used to determine the relative value of marijuana for each participant. Hits purchased on the MPT will correspond with actual number of hits purchased and smoked in the laboratory. Primary outcome is percentage of participants who purchased and smoked exactly what they said they would. | Duration of the experimental session (i.e., 60 minutes) | |
Secondary | Change in Marijuana Craving Questionnaire (MCQ) | Subjective marijuana craving was assessed via a 10-item Marijuana Craving Questionnaire. Participants were asked to respond to items according to how they were thinking or feeling "right now," and MCQ items were rated on a 1 = "strongly disagree" to 7 = "strongly agree" scale, with higher scores indicating greater subjective marijuana craving, and summed to yield a total craving score. Total craving score was used in analyses. | The MCQ will be administered pre- and post- marijuana smoking during the experimental session, up to 6 hours | |
Secondary | Marijuana Smoking Topography | Indices of Marijuana Smoking Topography will be obtained during the experimental session. Participants will smoke marijuana through a smoking topography device. The outcome measure is number of puffs. | Marijuana smoking topography indices will be collected during the 1-hour ad libitum marijuana smoking topography experimental session. |
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