Clinical Trials Logo
  1. Home
  2. Marijuana Dependence
  3. NCT00373295

Effect of Baclofen on Marijuana Withdrawal and Relapse

Marijuana Dependence Clinical Trial

Official title:
Effect of Baclofen on Marijuana Withdrawal and Relapse

Clinical Trial Summary

The purpose of this study is to determine if baclofen dose-dependently decreases marijuana's direct effects and symptoms of marijuana withdrawal and thus decreases marijuana relapse.

Clinical Trial Description

Only a small percentage of dependent-marijuana smokers who are seeking treatment for their marijuana use are able to achieve sustained abstinence. The objective of this study is to investigate the interaction between marijuana and the potential treatment medication, baclofen, with the direct goal of using this information to improve marijuana treatment outcome. GABAB agonists such as baclofen have been shown to attenuate the self-administration of cocaine, heroin, alcohol and nicotine (see Cousins et al., 2002; Haney et al., 2006). Baclofen also appears to decrease withdrawal symptoms in heroin and alcohol abusers (Akhondzadeh et al., 2000; Addolorato et al., 2000). The purpose of this study is to determine if baclofen dose-dependently decreases marijuana's direct effects and symptoms of marijuana withdrawal and thus decreases marijuana relapse in our laboratory model. For the purposes of this model, relapse is defined as a return to marijuana use after a period of abstinence. The study will utilize an inpatient/outpatient, counter-balanced design, with each participant maintained on each of three medication conditions for 16 days: placebo and baclofen (60, 90 mg/day). Participants will begin taking capsules during the outpatient phase so that the dose can be incremented up to the maintenance dose prior to the first inpatient day. Further, clinical studies have shown that baclofen is most effective at decreasing cocaine's effects when administered for several weeks. During the inpatient study phases, participants will have the opportunity to self-administer placebo or active marijuana 6 times per day. This study will provide important information of the effect of baclofen as a potential treatment medication for marijuana dependence. ;

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00373295
Study type Interventional
Source New York State Psychiatric Institute
Contact
Status Completed
Phase Phase 2
Start date May 2006
Completion date January 2010
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT00875836 - Buspirone Treatment for Marijuana Dependence Phase 4
Completed NCT00893269 - The Effect of Marijuana and Prescription Medications in Mood, Performance and Sleep Phase 1
Completed NCT00490269 - Ph1 Marinol Interaction Study - Part 2 - 1 Phase 1
Completed NCT02579421 - Hormones and Reduction in Co-users of Marijuana and Nicotine N/A
Terminated NCT01598896 - Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia Phase 2/Phase 3
Active, not recruiting NCT01827332 - Effect of Oxytocin on Craving and Therapy Response N/A
Completed NCT01335789 - Effect of Oxytocin on Stress in Marijuana Users N/A
Terminated NCT00438139 - Ph1 Marinol Interaction Study - Part 1 - 1 Phase 1
Completed NCT02955329 - Vaping THC From Electronic Cigarettes Phase 3
Completed NCT02439814 - Pregnenolone and Marijuana Dependence Phase 2
Completed NCT01039415 - Attempts to Stop/Reduce Marijuana Among Dependent Users N/A
Completed NCT01347762 - Nabilone for Cannabis Dependence: A Pilot Study Phase 2/Phase 3
Completed NCT00270803 - The Effects of Marijuana on Orientation and Motor Coordination and Brain Metabolism in Regular Smokers of Marijuana N/A
Completed NCT01020019 - Combined Pharmacotherapy for Cannabis Dependency Phase 2/Phase 3
Completed NCT02030665 - Marijuana Treatment Project 4 N/A
Completed NCT00107588 - Marijuana Treatment Project - 3 N/A
Completed NCT02011516 - Baclofen Effects on Marijuana Dependence Phase 2
Recruiting NCT00598052 - Treatment of Marijuana Withdrawal Syndrome Using Escitalopram and Cognitive-Behavior Therapy N/A
Completed NCT00350649 - Maximizing the Efficacy of Cognitive Behavior Therapy and Contingency Management Phase 2
Completed NCT00374127 - Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper Phase 2