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A Single-arm, Single-center, Open-label Phase II Study of Zanubrutinib Combined With R-CHOP/R-DHAP in Newly Diagnosed Mantle CellLymphoma Patients — Z+RCHOP/RDHAP  

Mantle Cell Lymphoma Clinical Trial

Official title:
A Single-arm, Single-center, Open-label Phase II Study of Zanubrutnib Combined With R-CHOP/R-DHAP Alternating Regimen for First-line MCL and Followed by Zanubrutinib Rituximab Maintenance Therapy

Clinical Trial Summary

Evaluation the efficacy and safety of Zanubrutinib + R-CHOP/R-DHAP for the treatment mantle cell lymphoma.

Clinical Trial Description

A single-arm, single-center, open-label phase II study of Zanubrutinib combined with R-CHOP/R-DHAP alternating induction therapy followed by Zanubrutinib rituximab maintenance therapy.The primary objective of this study was to assess CR and ORR rates after 6 cycles of initiation (i.e., at the end of induction therapy), and to collect adverse events during induction and maintenance therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06255704
Study type Interventional
Source Shanxi Province Cancer Hospital
Contact Liping Su, M.D.
Phone 13835158122
Email sulp2005@sohu.com
Status Not yet recruiting
Phase Phase 2
Start date March 15, 2024
Completion date December 1, 2027
View Details
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