| Eligibility |
Inclusion Criteria:
1. Have been fully informed about the study and have voluntarily signed the ICF;
2. Age = 18 years;
3. Histologically confirmed as B-cell NHL (pathology report), including DLBCL, FL, MZL,
and MCL, etc., and the disease requires further treatment;
4. Have relapsed/refractory disease or intolerance to prior therapy after = 2 prior lines
of therapy including anti-CD20 antibody-containing chemotherapy regimens (e.g.,
R-CHOP, etc.) (see Section 3.1 for specific definitions);
5. At least 1 radiographically measurable lesion (= 1 lymph node lesion with longest
diameter of > 1.5 cm, and/or extranodal lesion with longest diameter of >1.0 cm, as
assessed by computed tomography [CT]), and no prior radiotherapy on the lesion
(evidence of unequivocal progression is required if the lesion has received prior
radiotherapy);
6. ECOG score 0-2;
7. Adequate hematological status (supportive care such as growth factor, platelet
transfusion or blood transfusion or correction with drugs are not allowed within 5
days prior to screening):
Absolute neutrophil count (ANC) = 1.5 × 109/L Platelets = 75 × 109/L Hemoglobin = 9
g/dL Note: In Phase 2, if the investigator believes that the above values below the
lower limit of the protocol are due to bone marrow involvement by lymphoma, the
patient could be enrolled after consultation between investigator and the Sponsor and
obtaining written consent from the Sponsor;
8. Adequate hepatic, renal, and cardiac functions, defined as:
Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST)
- 2.5 × upper limit of normal (ULN); Total bilirubin = 1.5 × ULN, total bilirubin =
3 × ULN for patients with Gilbert's disease; Creatinine clearance = 50 mL/min as
estimated by the Cockcroft-Gault f formula (if < 50 mL/min, e.g., creatinine =
130 µmol/L is also allowed); Left ventricular ejection fraction = 45%; Note: In
Phase 2, the criteria for ALT or AST may be relaxed to = 5 × ULN if the
investigator assesses that the increase in ALT or AST is due to liver invasion by
lymphoma;
9. Male or female patients of childbearing potential must agree to use effective methods
of contraception, such as double barrier methods of contraception, condoms, oral or
injectable contraceptives, intrauterine devices, etc., during the study and within 90
days after the last dose of study drug. Postmenopausal women (> 45 years of age and
menopause for more than 1 year) and surgically sterilized women are not subject to
this condition.
Exclusion Criteria:
1. Chronic lymphocytic leukemia and T-cell malignancies;
2. Primary central nervous system lymphoma or lymphoma involving the central nervous
system;
3. Known history of hepatitis B (HBsAg positive) or hepatitis C (HCV antibody positive).
Subjects with occult or pre-hepatitis B infection (defined as HBcAb positive, HBsAg
negative) could be enrolled if HBV DNA test result is negative, and subjects with
serologically positive HCV antibody, such as negative HCV RNA test result, could also
be enrolled;
4. Known human immunodeficiency virus (HIV) infection;
5. Concomitant clinically significant active infections requiring systemic treatment,
including but not limited to chronic kidney infection, chronic chest infection with
bronchiectasis and tuberculosis, etc.;
6. Expected survival of no more than 24 weeks as judged by the investigator;
7. Previous solid organ transplant; autologous hematopoietic stem cell transplant,
allogeneic hematopoietic stem cell transplant, or chimeric antigen receptor T-cell
(CAR-T) therapy within 60 days prior to enrollment, or had the following conditions:
- Active graft versus host disease (GVHD);
- Cytopenia due to unrecovered hematopoiesis after transplantation;
- Anti-cytokine therapy (e.g., tocilizumab, glucocorticoids) is still required due
to CAR-T cell treatment toxicity, or neurological toxicity is > Grade 1 after
CAR-T cell therapy;
- Continuous use of immunosuppressive therapy;
8. Pregnant (positive pregnancy test at screening) or lactating female patients;
9. QTcF > 450 msec in male patients or QTcF > 470 msec in female patients or other
significant ECG abnormalities as judged by the investigator;
10. Toxicities due to prior anti-lymphoma therapy have not stabilized and have not
recovered to = Grade 1 (except for clinically insignificant toxicities such as
alopecia, etc.);
11. Other malignancies in the past 5 years, with the exception of radically treated basal
cell carcinoma of skin, breast cancer in situ and cervix carcinoma in situ;
12. The time from prior systemic anti-tumor therapy or investigational therapy to the
start of the planned study treatment is less than 4 weeks or 5 half-lives (whichever
is shorter);
13. History of acute myocardial infarction, unstable angina pectoris, stroke, intracranial
hemorrhage or transient ischemic attack within 6 months prior to enrollment; New York
Heart Association (NYHA) Grade 3 and 4 congestive heart failure;
14. History of deep vein thrombosis or pulmonary embolism within 6 months prior to
enrollment (Phase 1 dose escalation part only);
15. Grade = 2 sensory or motor neuropathy;
16. Known severe chronic obstructive pulmonary disease or asthma, defined as forced
expiratory volume in one second (FEV1) < 60% of expected value;
17. Prior therapies targeting CD74;
18. Insufficient compliance of patients participating in this clinical study as judged by
the investigator;
19. Any other disease, metabolic abnormality, physical examination abnormality, or
clinically significant laboratory abnormality, for which in the investigator's
judgment, there is reason to suspect that the patient has a disease or condition that
is not suitable for the study drug, or will affect the interpretation of the study
results, or place the patient at high risk (e.g., the suitability of patients for
inclusion in the study will be determined by the investigator if they have recovered
from COVID-19);
20. Live viral vaccination within 28 days prior to the first dose of study drug.
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