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EDOCH Alternating With DHAP for New Diagnosed Younger MCL — BDH-MCL01  

Mantle Cell Lymphoma Clinical Trial

Official title:
EDOCH Alternating With DHAP Regimen Combined Rituximab or Not to Treat New Diagnosed Younger (Age≤65 Years) Mantle Cell Lymphoma in China: A Multicentre Phase III Trial

Clinical Trial Summary

The purpose of this study is to:

1. determine the efficiency of EDOCH (etoposide,dexamethasone,doxorubicin, cyclophosphamide and vincristine) alternating with DHAP (cisplatin, cytarabine and dexamethasone) regimen combined with rituximab or not in young mantle cell lymphoma patients (age≤65 years);

2. determine the efficiency of rituximab and thalidomide plus prednisone as maintenance regimens.

Clinical Trial Description

Enrolled patients will receive EDOCH (etoposide,dexamethasone,doxorubicin, cyclophosphamide and vincristine) ±R /DHAP(cisplatin, cytarabine and dexamethasone) ±R alternating chemotherapy. If a partial remission or better response achieves, patients will be recommended to receive autologous stem cell transplantation as consideration therapy or another two cycles EDOCH ±R /DHAP±R chemotherapy (based on patient's choice). Patients with less than partial remission (PR) response will quit this study. After treatments finished, maintenance therapy with rituximab or thalidomide plus prednisone will be given less than two years. The determination of maintenance regimens is dependent on patients choices. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02858804
Study type Interventional
Source Institute of Hematology & Blood Diseases Hospital
Contact Shuhua Yi, Doc
Phone 86-22-23909106
Email yishuhua@ihcams.ac.cn
Status Recruiting
Phase Phase 4
Start date January 2016
Completion date June 2020
View Details
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