In-Vivo Activated T-Cell Depletion to Prevent GVHD

Status Terminated

Clinical Trial Summary

The purpose of this study is to compare the effects (good and bad) of the medication basiliximab in combination with cyclosporine with cyclosporine alone for the prevention of graft-versus-host disease.

This research is being done because there is no completely safe and effective prevention for graft-versus-host disease. It is known that cyclosporine helps with GVHD but we would like to know if the addition of basiliximab will decrease the incidence and/or severity of GVHD after a transplant known as nonmyeloablative ("mini" transplant).

Clinical Trial Description

n/a

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Acute Lymphocytic Leukemia
Acute Myelogenous Leukemia
Chronic Lymphocytic Leukemia
Chronic Myelogenous Leukemia
Hodgkin Disease
Hodgkin's Disease
Leukemia
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Lymphoid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Lymphoma
Lymphoma, Mantle-Cell
Lymphoma, Non-Hodgkin
Lymphoma, Non-Hodgkin's
Mantle-Cell Lymphoma
Multiple Myeloma
Myelodysplasia
Myelodysplastic Syndromes
Myelofibrosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Preleukemia

Clinical Trial Details

NCT number	NCT00594308
Study type	Interventional
Source	Indiana University
Contact
Status	Terminated
Phase	N/A
Start date	October 2007

View Details

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