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ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies — KEYNOTE145  

Multiple Myeloma Clinical Trial

Official title:
A Phase 1b/2 Proof-of-Concept Study of the Combination of ACP-196 (Acalabrutinib) and Pembrolizumab in Subjects With Hematologic Malignancies

Clinical Trial Summary

This study is evaluating the safety, pharmacodynamics (PD), and efficacy of acalabrutinib and pembrolizumab in hematologic malignancies.

Clinical Trial Description

This is a Phase 1b/2, open-label, nonrandomized study that will be conducted in 2 stages. In the first stage, Part 1 of the study will determine the safety and preliminary efficacy of acalabrutinib and pembrolizumab in a limited group of B-cell malignancies. In the second stage, Part 2 allows for possible expansion cohorts into a wider range of B-cell malignancies, and Part 3 will evaluate the combination in subjects with myelofibrosis (MF). ;

Study Design

Related Conditions & MeSH terms

  • Burkitt Lymphoma
  • CLL
  • Follicular Lymphoma (FL)
  • Hairy Cell Leukemia
  • Hematologic Neoplasms
  • Hodgkin Lymphoma
  • Indolent Non Hodgkin Lymphoma
  • Leukemia
  • Leukemia, Hairy Cell
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Lymphoma
  • Lymphoma, B-Cell, Marginal Zone
  • Lymphoma, Mantle-Cell
  • Mantle Cell Lymphoma (MCL)
  • Marginal Zone Lymphomas
  • Mediastinal Large B Cell Lymphoma
  • Multiple Myeloma
  • Neoplasms
  • Richter's Syndrome
  • Small Lymphocytic Lymphoma (SLL)
  • Waldenstrom Macroglobulinemia
  • Waldenström Macroglobulinemia
Clinical Trial Details
NCT number NCT02362035
Study type Interventional
Source Acerta Pharma BV
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date February 20, 2015
Completion date April 1, 2026
View Details
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