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Clinical Trial Summary

The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or recommended dose (RD) of SGR-1505.


Clinical Trial Description

This is a study of SGR-1505, an oral inhibitor of MALT1, in subjects with relapsed/refractory (R/R) B-cell lymphomas to evaluate the safety, pharmacokinetics (PK), pharmacodynamics (PD), maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or recommended dose (RD) of SGR-1505. Exploratory cohorts will evaluate additional PK, PD, preliminary anti-tumor activity, and safety to establish the SGR-1505 RD. A planned amendment will evaluate SGR-1505 in combination with other anti-cancer agents, such as BTK and BCL-2 inhibitors, in patients with specific B-cell malignancies. ;


Study Design


Related Conditions & MeSH terms

  • ALK-Positive Large B-Cell Lymphoma
  • Burkitt Lymphoma
  • Chronic Lymphocytic Leukemia
  • DLBCL
  • DLBCL Germinal Center B-Cell Type
  • EBV-Positive DLBCL, Nos
  • Follicular Lymphoma
  • High-grade B-cell Lymphoma
  • Leukemia, Lymphocytic, Chronic, B-Cell
  • Lymphoma
  • Lymphoma, B-Cell
  • Lymphoma, B-Cell, Marginal Zone
  • Lymphoma, Follicular
  • Lymphoma, Large B-Cell, Diffuse
  • Lymphoma, Large-Cell, Immunoblastic
  • Lymphoma, Mantle-Cell
  • Lymphoplasmacytic Lymphoma
  • MALT Lymphoma
  • Mantle Cell Lymphoma
  • Mature B-Cell Neoplasm
  • Neoplasms
  • Nodal Marginal Zone Lymphoma
  • Non Hodgkin Lymphoma
  • Plasmablastic Lymphoma
  • Primary Effusion Lymphoma
  • Primary Mediastinal Large B Cell Lymphoma
  • Splenic Marginal Zone Lymphoma
  • Waldenstrom Macroglobulinemia

NCT number NCT05544019
Study type Interventional
Source Schrödinger, Inc.
Contact Study Physician
Phone +15032991150
Email sdgr-trials-group@schrodinger.com
Status Recruiting
Phase Phase 1
Start date April 10, 2023
Completion date March 2026

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