Malnutrition Clinical Trial
Official title:
Exchangeable Zn Pool Size and Zn Absorption From Sprinkles and Traditional Foods in Pakistani Infants/Toddlers
The broad objective is to improve zinc status in older infants and young children who are at risk of zinc deficiency because of combination of inadequate dietary zinc intake and high rates of diarrhea. As a sub-study within larger RCT using zinc fortified Sprinkles, the proposed study will measure the amount of zinc absorbed from a test meal of typical unfortified complementary foods consumed by Pakistani infants, or the same complementary foods fortified by the addition of the Zn-containing Sprinkle.
In the nested study we aim to measure from a subgroup of recruited children in the main
study, the amount of zinc absorbed from typical unfortified complementary foods consumed by
Pakistani infants, and compare it with the same complementary food fortified by the addition
of the Zn-containing Sprinkles and multi vitamins. Since EZP Exchangeable Zinc Pool is
considered to be the gold standard for estimation of the actual concentration of zinc in the
plasma that is readily available for cellular function, we would also calculate the EZP in
this subset of samples.
The specific aim of the nested study will :
1. Determine absorption of zinc (Zn) from a test meal consisting of typical local food with
addition of a multiple-micronutrient Sprinkles product containing (10 mg of Zn) vs
absorption from the same meal without zinc supplementation to those with no
micronutrient fortification.
2. Compare size of exchangeable Zn pool (EZP) for subjects who have been randomized to
receive multi-micronutrient Sprinkle (MN) only with those who were randomized to (MN+Zn
) with control group.
3. Children will be followed for growth monitoring for at least 2 years.
4. Plasma zinc and phytates levels in the weaning diet will also be assessed.
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