Nutritional Status Among Older Adults. Risk Factors and Consequences of Malnutrition

Malnutrition Clinical Trial

Official title:

Nutritional Status Among Older Adults. Risk Factors and Consequences of Malnutrition

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01161342
• Other study ID #: LTV-1211142
• Status: Completed
• Phase: N/A
• First received: July 12, 2010
• Last updated: August 25, 2015
• Start date: March 2008
• Est. completion date: May 2009

Study information

• Verified date: May 2011
• Source: Uppsala University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Sweden: Regional Ethical Review Board
• Study type: Observational

Clinical Trial Summary

The aim of the study is to estimate the prevalence of malnutrition among older adults admitted to hospital and to analyse predictive factors for malnutrition. Further, the aim was to analyse the association between nutritional status and all-cause and cause-specific mortality.

The hypothesis is that malnourished patients have a higher mortality then well-nourished patients after three years.

Description:

The baseline survey was a cross-sectional study of 1771 patients aged ≥65 years who were admitted to hospital. Nutritional status was assessed using the MNA instrument, and possible risk factors associated with malnutrition were recorded during the hospital stay. All-cause mortality was followed up after median 3.5 years s in a cohort study of 1767 participants. Cause-specific mortality was followed up after median 4.7 years in a cohort of 1767 participants. Previous dietary intake in middle-aged and older adults was recorded at basline in 725 participants, who had their nutritional status assessed with the MNA when admitted to hospital 10 years later.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1771
• Est. completion date: May 2009
• Est. primary completion date: May 2009
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• Patients 65 years or older

Exclusion Criteria:

• unable to communicate and no relative could anwer the questions (n = 356)

• receiving palliative care (n = 44)

• impossible to measure height or weight (n = 22)

• miscellanious (n = 71)

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Malnutrition

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
Uppsala University	Ministry of Health and Social Affairs, Sweden

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Nutritional status according to the screening instrument Mini Nutritional Assessment (MNA)	[The 18 questions in the MNA instrument are weighted, and the threshold values of the instrument categorize patients into three nutritional status groups: well-nourished (MNA score 24-30), at risk of malnutrition (MNA score 17-23.5), or malnourished (MNA score <17).	30 minutes	No
Primary	All-cause mortality	Survival was calculated from the date of the MNA screening to the date of death.	All-cause mortality was analyzed after median 3.5 years.	No
Primary	Cause-specific mortality	Survival was calculated from the date of the MNA screening to the date of cause-specific death.	Cause-specific mortality was analyzed after median 4.7 years.	No