Probiotics Use in the Chronic Peritoneal Dialysis Patients

Malnutrition Clinical Trial

Official title: The Clinical Use of Probiotics in the Uremia Patients Under Chronic Peritoneal Dialysis

Status Recruiting

Clinical Trial Summary

The purpose of this study is to determine whether probiotics can improve the nutrition status and prevent peritonitis in the chronic peritoneal dialysis patients.

Clinical Trial Description

Peritoneal dialysis was one of therapies for uremia patient. However, peritoneal dialysis related peritonitis was a major complication for these patients. Severe and prolong peritonitis may led to membrane failure and drop out of peritoneal dialysis. Among the pathogens, G(+) bacteria came from skin surface and G(-) bacteria came from gastrointestinal tract. The later might be related to the pathogens in the gastrointestinal tract, and led to peritonitis if constipation or diarrhea developed. In addition, intestinal pathogens may be related to chronic inflammation in uremia patients. There was a MIA syndrome (malnutrition, inflammation and atherosclerosis) noted before, and chronic inflammation may be related to malnutrition. Today, we know that nutrition status and inflammation marker (CRP) may be associated with patients' outcome. Many gastrointestinal syndromes such as constipation suffer our patients. The dialysate in the abdominal cavity may further exacerbate the appetite. The probiotics was though to improve the pathogens in intestinal tract, improve gastrointestinal function. We want to decrease the incidence of peritonitis by using the probiotics. In addition, the improvement in gastrointestinal function can increase the nutrition status. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Malnutrition
• Peritonitis

• NCT number: NCT01076426
• Study type: Interventional
• Source: National Cheng-Kung University Hospital
• Contact: An-Bang Wu, MD
• Phone: 886-6-2353535
• Email: anbang@mail.ncku.edu.tw
• Status: Recruiting
• Phase: Phase 4
• Start date: February 2010
• Completion date: March 2011