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Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma — PENINSULA  

Malignant Pleural Mesothelioma Clinical Trial

Official title:
First-line Pembrolizumab Plus Platinum Doublet Chemotherapy With Lenvatinib in Unresectable Malignant Pleural Mesotheliomaļ¼šMulti-Institutional, Single-Arm Phase 2 Trial

Clinical Trial Summary

In this Phase-II study, the investigators will investigate the efficacy and safety of lenvatinib in combination with pembrolizumab and chemotherapy in patients with malignant pleural mesothelioma.

Clinical Trial Description

This is a single-arm, open-label study to evaluate the efficacy and safety of lenvatinib in combination with pembrolizumab and chemotherapy in patients with malignant pleural mesothelioma. The study will consist of a screening phase, a treatment phase, and a follow-up phase. Patients who meet the Inclusion Criteria, do not meet the Exclusion Criteria, and are judged by the investigator to be eligible for this clinical trial will be included. Subjects who meet all of the criteria listed in Criteria for Administration of Investigational Drugs may continue to receive the investigational drug. If a subject receiving investigational drugs meets any of the criteria listed in Discontinuation Criteria of Investigational Drugs, the subject will be evaluated at the end of the treatment phase (at the time of discontinuation) and moved to the post-observation phase. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06318286
Study type Interventional
Source Hyogo Medical University
Contact Kozo Kuribayashi, MD, PhD
Phone +81-798-45-6596
Email kuririn@hyo-med.ac.jp
Status Not yet recruiting
Phase Phase 2
Start date March 13, 2024
Completion date October 30, 2026
View Details
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