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A Phase II Study of PF-03446962 in Patients With Advanced Malignant Pleural Mesothelioma

Malignant Pleural Mesothelioma Clinical Trial

Official title:
A Phase II Study of PF-03446962 in Patients With Advanced Malignant Pleural Mesothelioma

Clinical Trial Summary

This is a non-randomized open label multicentre Phase II trial to evaluate the response rate of PF03446962 in patients with advanced malignant pleural mesothelioma who have been previously treated with cytotoxic chemotherapy.

Clinical Trial Description

To assess the efficacy (response rate, complete and partial) of PF-03446962 given by IV infusion Day 1 of a 2 week cycle (14 days = 1 cycle) in patients with advanced malignant pleural mesothelioma and previously treated with cytotoxic therapy. To assess the toxicity, safety and tolerability of PF-03446962. To assess the duration of response or stable disease, stable disease rate, progression-free, median and overall survival rates. To collect tissue and blood for banking and correlative science evaluation. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01486368
Study type Interventional
Source Canadian Cancer Trials Group
Contact
Status Completed
Phase Phase 2
Start date June 26, 2012
Completion date February 13, 2015
View Details
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